NRG1 and ADAM19

Data Source:
HPRD (in vitro)

		NRG1	ADAM19
Description		neuregulin 1	ADAM metallopeptidase domain 19
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Plasma Membrane Membrane Integral Component Of Membrane	Nucleus Golgi Apparatus Plasma Membrane Integral Component Of Membrane Collagen-containing Extracellular Matrix
	Molecular Function	Transcription Coregulator Activity Signaling Receptor Binding Cytokine Activity Integrin Binding Growth Factor Activity Protein Tyrosine Kinase Activator Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Tyrosine Kinase Binding ErbB-3 Class Receptor Binding Chemorepellent Activity	Metalloendopeptidase Activity Protein Binding SH3 Domain Binding Metal Ion Binding Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
	Biological Process	MAPK Cascade Activation Of MAPK Activity Ventricular Trabecula Myocardium Morphogenesis Cell Communication Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Nervous System Development Positive Regulation Of Cell Population Proliferation Neural Crest Cell Development Cell Differentiation Mammary Gland Development Positive Regulation Of Protein-containing Complex Assembly Activation Of Protein Kinase B Activity Intracellular Signal Transduction ERBB Signaling Pathway ERBB2 Signaling Pathway ERBB3 Signaling Pathway Wound Healing Negative Regulation Of Transcription, DNA-templated Animal Organ Development Negative Chemotaxis Negative Regulation Of Secretion Positive Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Cardiac Muscle Cell Differentiation Cardiac Muscle Cell Myoblast Differentiation Endocardial Cell Differentiation Positive Regulation Of Protein Tyrosine Kinase Activity Regulation Of Cell Motility	Placenta Development Membrane Protein Ectodomain Proteolysis Positive Regulation Of Gene Expression Protein Processing Extracellular Matrix Organization Amyloid Precursor Protein Catabolic Process Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Long-term potentiation Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants	Invadopodia formation
Drugs
Diseases
GWAS		Bone mineral density (hip) ( 30172743) Cardiac Troponin-T levels ( 23247143) Cerebrospinal P-tau181p levels ( 28247064) Cerebrospinal T-tau levels ( 28247064) Chin dimples ( 27182965) Chronotype ( 30696823) Cleft lip with or without cleft palate ( 28054174) Cognitive function ( 25644384) Coronary artery calcification ( 23870195) Dialysis-related mortality ( 21546767) Differentiated thyroid cancer ( 28703219) Diffusing capacity of carbon monoxide ( 30694715) Emphysema imaging phenotypes ( 26030696) Estimated glomerular filtration rate ( 31152163 30604766) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hip geometry ( 17903296) Hirschsprung disease ( 19196962 25310821 27702942) Hypothyroidism ( 27182965) Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Major depressive disorder ( 29317602) Malaria ( 31844061) Metabolite levels (X-11787) ( 23934736) Morning person ( 30696823) Non-small cell lung cancer ( 31326317) Obstructive sleep apnea ( 25325441) Orofacial clefts ( 28054174) Papillary thyroid cancer ( 28703219) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pulse pressure ( 27841878) Refractive astigmatism ( 25367360) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834) Serum thyroid-stimulating hormone levels ( 25436638) Thyroid cancer ( 22267200) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Urate levels ( 31578528) Weight ( 28552196)	Asthma ( 31959851) Blood protein levels ( 30072576) Body mass index ( 28552196) Chronic obstructive pulmonary disease ( 28166215 30804561) Eosinophil percentage of white cells ( 32888494) FEV1 ( 30804560) Inflammatory skin disease ( 25574825) Lung function (FEV1/FVC) ( 28166213 30804560) Medication use (adrenergics, inhalants) ( 31015401) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Peak expiratory flow ( 30804560) Pulmonary function ( 20010835) Pulmonary function (smoking interaction) ( 23284291) T-Cell Immunoglobulin and Mucin domain 1 levels ( 32460577) Triglyceride levels ( 31647587)
Interacting Genes		15 interacting genes: ADAM19 ASGR2 CD72 EGF EGFR ERBB2 ERBB3 ERBB4 IKZF4 JAGN1 LAPTM4B LIMK1 MS4A4A PLP1 TMEM54	7 interacting genes: A2M ABI2 COPB1 FURIN NRG1 SH3GL2 TNFSF11
Entrez ID		3084	8728
HPRD ID		00802	04704
Ensembl ID		ENSG00000157168	ENSG00000135074
Uniprot IDs		A0A024QY88 A0A494C0K4 A0A494C0L9 A0A494C0Q4 A0A494C114 A0A494C1B5 A0A494C1F5 A0A494C1F8 A5YAK6 A5YAK8 A6MW54 A6MW55 A6MW56 B0FWZ3 B0FYA7 B0FYA8 B0FYA9 B7Z1D7 B7Z1E3 E3SFM9 F6RJN6 Q02297 Q6PK61 Q7RTW3 Q7RTW5	Q8TBU7 Q9H013
PDB IDs		1HAE 1HAF 1HRE 1HRF 3U7U
Enriched GO Terms of Interacting Partners?
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