NRG1 and JAGN1

Data Source:
BioGRID (two hybrid)

		NRG1	JAGN1
Description		neuregulin 1	jagunal homolog 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Plasma Membrane Membrane Integral Component Of Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Transcription Coregulator Activity Signaling Receptor Binding Cytokine Activity Integrin Binding Growth Factor Activity Protein Tyrosine Kinase Activator Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Tyrosine Kinase Binding ErbB-3 Class Receptor Binding Chemorepellent Activity	Protein Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Ventricular Trabecula Myocardium Morphogenesis Cell Communication Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Nervous System Development Positive Regulation Of Cell Population Proliferation Neural Crest Cell Development Cell Differentiation Mammary Gland Development Positive Regulation Of Protein-containing Complex Assembly Activation Of Protein Kinase B Activity Intracellular Signal Transduction ERBB Signaling Pathway ERBB2 Signaling Pathway ERBB3 Signaling Pathway Wound Healing Negative Regulation Of Transcription, DNA-templated Animal Organ Development Negative Chemotaxis Negative Regulation Of Secretion Positive Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Protein Kinase B Signaling Cardiac Muscle Cell Differentiation Cardiac Muscle Cell Myoblast Differentiation Endocardial Cell Differentiation Positive Regulation Of Protein Tyrosine Kinase Activity Regulation Of Cell Motility	Neutrophil Mediated Immunity Exocytosis Endoplasmic Reticulum Organization Protein Transport Vesicle-mediated Transport Neutrophil Differentiation Granulocyte Colony-stimulating Factor Signaling Pathway Defense Response To Fungus Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cellular Response To Tunicamycin Neutrophil Migration
Pathways		Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Long-term potentiation Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS		Bone mineral density (hip) ( 30172743) Cardiac Troponin-T levels ( 23247143) Cerebrospinal P-tau181p levels ( 28247064) Cerebrospinal T-tau levels ( 28247064) Chin dimples ( 27182965) Chronotype ( 30696823) Cleft lip with or without cleft palate ( 28054174) Cognitive function ( 25644384) Coronary artery calcification ( 23870195) Dialysis-related mortality ( 21546767) Differentiated thyroid cancer ( 28703219) Diffusing capacity of carbon monoxide ( 30694715) Emphysema imaging phenotypes ( 26030696) Estimated glomerular filtration rate ( 31152163 30604766) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hip geometry ( 17903296) Hirschsprung disease ( 19196962 25310821 27702942) Hypothyroidism ( 27182965) Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Major depressive disorder ( 29317602) Malaria ( 31844061) Metabolite levels (X-11787) ( 23934736) Morning person ( 30696823) Non-small cell lung cancer ( 31326317) Obstructive sleep apnea ( 25325441) Orofacial clefts ( 28054174) Papillary thyroid cancer ( 28703219) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pulse pressure ( 27841878) Refractive astigmatism ( 25367360) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834) Serum thyroid-stimulating hormone levels ( 25436638) Thyroid cancer ( 22267200) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Urate levels ( 31578528) Weight ( 28552196)
Interacting Genes		15 interacting genes: ADAM19 ASGR2 CD72 EGF EGFR ERBB2 ERBB3 ERBB4 IKZF4 JAGN1 LAPTM4B LIMK1 MS4A4A PLP1 TMEM54	126 interacting genes: AGPAT4 APP AQP6 ARL13B BCL2L13 BET1 BMP10 BNIP1 BNIP3 BSND BTNL9 C4orf3 CALHM6 CCL4L2 CD79A CDIPT CERS4 CGRRF1 CLDN7 CLEC12B CLEC4D CLEC7A CMTM5 COX20 CREB3L1 CYBC1 CYP4F2 DNAJC30 EBP EDA2R EHHADH ELOVL4 ERG28 ERGIC3 F11R FAM177A1 FAM209A FCGR1A FCRL2 FCRL4 FDFT1 FIS1 FKBP8 FNDC9 FRMD3 FXYD6 GIMAP1 GIMAP5 GJB5 GOLM1 GOSR2 GP2 GPR152 GPR37L1 HMOX1 HSD17B13 HTATIP2 ICMT IER3IP1 IFNGR2 IL3RA KASH5 KCNA1 KIR2DL3 KIR3DL3 LEMD1 LHFPL5 LMNA LPAR3 MFF MRM3 MTIF3 NINJ2 NRG1 OTULINL PDZK1IP1 PLP1 PLPP2 PSCA RETREG3 RTP2 SACM1L SAR1A SCD SEC22B SERP1 SLAMF6 SLC16A2 SLC23A2 SLC34A2 SMAGP SMIM1 SMIM19 STOML3 STX1A STX3 STX5 STX7 STX8 TECR TIMM23 TMEM100 TMEM106C TMEM120B TMEM128 TMEM14B TMEM199 TMEM207 TMEM237 TMEM242 TMEM243 TMEM52B TMEM65 TMIE TNFSF14 TREX1 TSNARE1 UBE2J1 USE1 VAMP2 VAMP5 VAPA VAPB VKORC1 VSIG4 VTI1B
Entrez ID		3084	84522
HPRD ID		00802	13749
Ensembl ID		ENSG00000157168	ENSG00000171135
Uniprot IDs		A0A024QY88 A0A494C0K4 A0A494C0L9 A0A494C0Q4 A0A494C114 A0A494C1B5 A0A494C1F5 A0A494C1F8 A5YAK6 A5YAK8 A6MW54 A6MW55 A6MW56 B0FWZ3 B0FYA7 B0FYA8 B0FYA9 B7Z1D7 B7Z1E3 E3SFM9 F6RJN6 Q02297 Q6PK61 Q7RTW3 Q7RTW5	Q8N5M9
PDB IDs		1HAE 1HAF 1HRE 1HRF 3U7U
Enriched GO Terms of Interacting Partners?
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