H2BC3 and USP43

Data Source:
BioGRID (enzymatic study)

		H2BC3	USP43
Description		H2B clustered histone 3	ubiquitin specific peptidase 43
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleosome Nucleus Nucleoplasm Cytosol	Nucleoplasm
	Molecular Function	DNA Binding Protein Binding Protein Heterodimerization Activity	Thiol-dependent Ubiquitin-specific Protease Activity ISG15-specific Protease Activity
	Biological Process	Nucleosome Assembly Protein Ubiquitination	Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Protein Phosphopantetheinylation Translesion Synthesis
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Amyloid fiber formation	Termination of translesion DNA synthesis
Drugs
Diseases
GWAS			Coronary artery disease ( 29212778)
Interacting Genes		25 interacting genes: AKT1 APP CDK1 CDK2 CREBBP DYRK1A EID1 EP300 ERCC6 FANCD2 H2AC4 KAT2B MYB PALB2 PSMD4 RHBDD2 RNF20 RNF8 RPS6KA5 UBR7 UHRF1 USP16 USP36 USP43 USP51	3 interacting genes: H2BC3 HDAC1 YWHAE
Entrez ID		3018	124739
HPRD ID		07536	18926
Ensembl ID		ENSG00000276410	ENSG00000154914
Uniprot IDs		P33778	Q70EL4
PDB IDs		3X1S 3X1U
Enriched GO Terms of Interacting Partners?
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