EFEMP2 and ZNF263

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EFEMP2	ZNF263
Description		EGF containing fibulin extracellular matrix protein 2	zinc finger protein 263
Image			No pdb structure
GO Annotations	Cellular Component	Microfibril Extracellular Region Basement Membrane Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome Elastic Fiber Extracellular Vesicle	Nucleus
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Heparin Binding Protein Homodimerization Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Aorta Development Elastic Fiber Assembly Aorta Smooth Muscle Tissue Morphogenesis Vascular Associated Smooth Muscle Cell Development Regulation Of Collagen Fibril Organization Positive Regulation Of Collagen Fibril Organization Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Positive Regulation Of Smooth Muscle Cell-matrix Adhesion	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres	Generic Transcription Pathway
Drugs
Diseases		Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS		Acne (severe) ( 24927181) Adult body size ( 32376654) Birth weight ( 31043758) Body size at age 10 ( 32376654) Retinal detachment or retinal break ( 31816047)
Interacting Genes		130 interacting genes: ADAMTSL4 AMMECR1 ANAPC11 AP1M1 APEX2 AQP1 ARRDC3 ATN1 ATXN1 ATXN7 BAG6 C3 C5orf24 CACNA1A CATSPER1 CCDC33 CCND3 CCNK CDPF1 CLPP CNNM3 COL8A1 CREB5 CXCL5 CYSRT1 DGCR6 DOK7 FAM107A FAM110A FAM124B FAM74A4 FAM90A1 FBXW5 FTO GFI1B GLRX3 HDAC4 HHEX HHIPL1 HOXA1 HPCAL1 HSD3B7 HSPA12B HSPBP1 IGFBP6 IL16 INCA1 ITGB5 KLF1 KRTAP10-8 KRTAP11-1 KRTAP12-2 KRTAP13-3 KRTAP19-5 KRTAP26-1 KRTAP3-2 LBX1 LCE1A LCE1C LCE1E LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LINGO1 LNX1 MDFI MEOX2 MRPL12 MXI1 NEDD4L NOS3 NR1D2 NTM NUFIP2 OTX1 P2RX7 PIDD1 PITX1 PLSCR1 PLSCR4 PROP1 PRPF31 PRR32 PTGER3 RAB40B RBAK RBP3 RBPMS RERE RHOXF2 RHPN1 RIBC2 RNF138 SGTA SGTB SLC16A5 SLC23A1 SLC25A48 SPACA9 SPATA24 SPATA3 SPATA8 SPRY4 STK16 TCAF1 THAP7 TLE5 TLX3 TP53 TRIB3 TRIM42 UBQLN1 UBQLN4 USP21 ZNF263 ZNF345 ZNF426 ZNF558 ZNF57 ZNF581 ZNF587 ZNF638 ZNF670 ZNF699 ZNF768 ZNF774 ZNF837	20 interacting genes: CLK2 CLK3 DVL2 EFEMP2 GPATCH2L JAKMIP2 LNX1 NME7 PCBD1 PLEKHF2 PPL SCAND1 SPG21 SUFU TCAF1 TRIM41 ZNF165 ZNF446 ZSCAN1 ZSCAN22
Entrez ID		30008	10127
HPRD ID		05221	05008
Ensembl ID		ENSG00000172638	ENSG00000006194
Uniprot IDs		A0A024R5G1 O95967 Q9H3D5	D3DUC1 O14978
PDB IDs		2KL7
Enriched GO Terms of Interacting Partners?
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