FHOD1 and CR2

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		FHOD1	CR2
Description		formin homology 2 domain containing 1	complement C3d receptor 2
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GO Annotations	Cellular Component	Stress Fiber Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Intercalated Disc Membrane Bleb	Plasma Membrane Integral Component Of Membrane Receptor Complex Extracellular Exosome
	Molecular Function	Protein Binding Protein Domain Specific Binding Identical Protein Binding Protein Self-association Actin Filament Binding	Virus Receptor Activity Complement Binding DNA Binding Complement Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Nuclear Migration Cortical Actin Cytoskeleton Organization Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly Actin Filament Network Formation Establishment Of Centrosome Localization	Complement Receptor Mediated Signaling Pathway Immune Response Complement Activation, Alternative Pathway Complement Activation, Classical Pathway B Cell Differentiation Regulation Of Complement Activation B Cell Proliferation Viral Entry Into Host Cell
Pathways			Regulation of Complement cascade
Drugs
Diseases
GWAS			Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Refractive error ( 32231278) Systemic sclerosis ( 29293537) Type 2 diabetes ( 21490949)
Interacting Genes		22 interacting genes: ACTA1 ACTG1 APC BBS1 BBS2 BBS4 BBS7 CR2 EXOSC8 GRB2 LNPEP NCOA6 NLGN3 PFN2 PPARG PRKG1 RAC1 RANBP2 RNF5 TRIM21 YWHAZ ZMYND8	10 interacting genes: ANXA6 C3 CD19 CR1 FCER2 FHOD1 HNRNPU IFITM1 IFNA1 TP53
Entrez ID		29109	1380
HPRD ID		06049	00399
Ensembl ID		ENSG00000135723	ENSG00000117322
Uniprot IDs		A0A068F7M9 Q9Y613	P20023
PDB IDs		3DAD	1GHQ 1LY2 1W2R 1W2S 2ATY 2GSX 3OED
Enriched GO Terms of Interacting Partners?
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