BABAM1 and GATAD2A

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, proximity labelling technology)

		BABAM1	GATAD2A
Description		BRISC and BRCA1 A complex member 1	GATA zinc finger domain containing 2A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body BRCA1-A Complex BRISC Complex	Nucleus Nucleoplasm NuRD Complex Nuclear Speck
	Molecular Function	Protein Binding	Protein Binding Zinc Ion Binding Protein-macromolecule Adaptor Activity Sequence-specific DNA Binding
	Biological Process	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Cell Cycle Response To Ionizing Radiation Protein Deubiquitination Positive Regulation Of DNA Repair Cell Division Protein K63-linked Deubiquitination Signal Transduction Involved In G2 DNA Damage Checkpoint	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Negative Regulation Of Transcription, DNA-templated
Pathways		Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS
Drugs
Diseases
GWAS		Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Epithelial ovarian cancer ( 25581431) Mitochondrial DNA copy number ( 30704525)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Height ( 25282103 31562340) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Nonalcoholic fatty liver disease ( 29385134) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 30578418) Red cell distribution width ( 28957414) Refractive error ( 32231278) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 25056061 29483656 23974872) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Strenuous sports or other exercises ( 29899525) Type 2 diabetes ( 28869590)
Interacting Genes		8 interacting genes: AKT1 BABAM2 BRCA1 SHMT2 TERF2IP TNKS TRIM27 UBC	15 interacting genes: CBFA2T3 CREBBP H2AC20 H2BC21 H3C1 H4C1 KAT2B KRT32 KRT34 KRT40 MBD2 MBD3 MBD3L1 PAK4 SPOP
Entrez ID		29086	54815
HPRD ID		13702	11741
Ensembl ID		ENSG00000105393	ENSG00000167491
Uniprot IDs		A0A024R7L2 J3KQS6 Q9NWV8	A0A024R7K7 A0A024R7M6 Q86YP4
PDB IDs		6H3C	2L2L
Enriched GO Terms of Interacting Partners?
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