GATAD2A and KRT32

Data Source:
BioGRID (two hybrid)

		GATAD2A	KRT32
Description		GATA zinc finger domain containing 2A	keratin 32
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm NuRD Complex Nuclear Speck	Cytosol Intermediate Filament Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Protein-macromolecule Adaptor Activity Sequence-specific DNA Binding	Structural Molecule Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Negative Regulation Of Transcription, DNA-templated	Epidermis Development Keratinization Cornification
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS	Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Height ( 25282103 31562340) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Nonalcoholic fatty liver disease ( 29385134) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 30578418) Red cell distribution width ( 28957414) Refractive error ( 32231278) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 25056061 29483656 23974872) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Strenuous sports or other exercises ( 29899525) Type 2 diabetes ( 28869590)
Interacting Genes		15 interacting genes: CBFA2T3 CREBBP H2AC20 H2BC21 H3C1 H4C1 KAT2B KRT32 KRT34 KRT40 MBD2 MBD3 MBD3L1 PAK4 SPOP	9 interacting genes: CCDC187 GATAD2A KIFC3 KRT72 KRT80 KRT86 NEDD9 TCHP UBASH3A
Entrez ID		54815	3882
HPRD ID		11741	04134
Ensembl ID		ENSG00000167491	ENSG00000108759
Uniprot IDs		A0A024R7K7 A0A024R7M6 Q86YP4	Q14532
PDB IDs		2L2L
Enriched GO Terms of Interacting Partners?
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