BABAM1 and SHMT2

Data Source:
BioGRID (pull down)

		BABAM1	SHMT2
Description		BRISC and BRCA1 A complex member 1	serine hydroxymethyltransferase 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body BRCA1-A Complex BRISC Complex	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Cytosol Microtubule Cytoskeleton Mitochondrial Nucleoid Extracellular Exosome BRISC Complex
	Molecular Function	Protein Binding	Translation Repressor Activity, MRNA Regulatory Element Binding Chromatin Binding Glycine Hydroxymethyltransferase Activity Protein Binding Zinc Ion Binding L-allo-threonine Aldolase Activity Pyridoxal Phosphate Binding Protein Homodimerization Activity MRNA 5'-UTR Binding Cobalt Ion Binding Serine Binding
	Biological Process	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Cell Cycle Response To Ionizing Radiation Protein Deubiquitination Positive Regulation Of DNA Repair Cell Division Protein K63-linked Deubiquitination Signal Transduction Involved In G2 DNA Damage Checkpoint	Regulation Of Oxidative Phosphorylation Glycine Metabolic Process L-serine Metabolic Process L-serine Biosynthetic Process L-serine Catabolic Process One-carbon Metabolic Process Positive Regulation Of Cell Population Proliferation Purine Nucleobase Biosynthetic Process Negative Regulation Of Translation Glycine Biosynthetic Process From Serine Response To Type I Interferon Tetrahydrofolate Interconversion Tetrahydrofolate Metabolic Process Folic Acid Metabolic Process Protein Tetramerization Protein Homotetramerization Regulation Of Mitochondrial Translation Protein K63-linked Deubiquitination Regulation Of Aerobic Respiration
Pathways		Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	Metabolism of folate and pterines
Drugs			Pyridoxal phosphate Tetrahydrofolic acid Glycine Artenimol
Diseases
GWAS		Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Epithelial ovarian cancer ( 25581431) Mitochondrial DNA copy number ( 30704525)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Schizophrenia ( 25056061 29483656)
Interacting Genes		8 interacting genes: AKT1 BABAM2 BRCA1 SHMT2 TERF2IP TNKS TRIM27 UBC	18 interacting genes: ABRAXAS2 APP ARL6IP1 BABAM1 BABAM2 BRCC3 CAB39 CLEC2D CMTM5 CREB3 CSNK2B DUX4 ESR1 FBXO7 KASH5 MAL2 NDRG1 PPARD
Entrez ID		29086	6472
HPRD ID		13702	00717
Ensembl ID		ENSG00000105393	ENSG00000182199
Uniprot IDs		A0A024R7L2 J3KQS6 Q9NWV8	A0A024RB99 B4DJQ3 B4DLV4 P34897 Q5BJF5 Q5HYG8 V9HW06
PDB IDs		6H3C	4PVF 5V7I 5X3V 6DK3 6H3C 6QVG 6QVL 6R8F
Enriched GO Terms of Interacting Partners?
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