CHMP4A and CDK13

Data Source:
HPRD (two hybrid)

		CHMP4A	CDK13
Description		charged multivesicular body protein 4A	cyclin dependent kinase 13
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GO Annotations	Cellular Component	ESCRT III Complex Nucleus Cytoplasm Endosome Multivesicular Body Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Coat Midbody Cytoplasmic Vesicle Membrane Late Endosome Membrane	Cyclin-dependent Protein Kinase Holoenzyme Complex Cyclin K-CDK13 Complex Extracellular Region Extracellular Space Nucleus Nucleoplasm Golgi Apparatus Cytosol Cyclin/CDK Positive Transcription Elongation Factor Complex Nuclear Speck Nuclear Cyclin-dependent Protein Kinase Holoenzyme Complex Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding Protein Homodimerization Activity ATPase Binding	RNA Binding Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Protein Kinase Binding Cyclin Binding
	Biological Process	Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Vesicle Budding From Membrane Nucleus Organization Mitotic Metaphase Plate Congression Membrane Invagination Endosomal Transport Macroautophagy Viral Life Cycle Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Protein Polymerization Midbody Abscission Plasma Membrane Tubulation Negative Regulation Of Neuron Death Negative Regulation Of Autophagosome Assembly	Alternative MRNA Splicing, Via Spliceosome Transcription Elongation From RNA Polymerase II Promoter Protein Phosphorylation Regulation Of Mitotic Nuclear Division Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Viral Process Hemopoiesis Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Neutrophil Degranulation Phosphorylation Of RNA Polymerase II C-terminal Domain Negative Regulation Of Stem Cell Differentiation
Pathways		Budding and maturation of HIV virion Macroautophagy Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex	TP53 Regulates Transcription of DNA Repair Genes Neutrophil degranulation
Drugs
Diseases
GWAS			Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Plateletcrit ( 32888494) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		14 interacting genes: CC2D1A CDK13 CHMP3 CHMP4B CHMP4C CHMP5 CHMP6 NTAQ1 NUTF2 PDCD6IP STAMBP SYT17 TTC19 VPS4A	4 interacting genes: CHMP4A PRPF40A SRPK2 TRIM7
Entrez ID		29082	8621
HPRD ID		16597	04496
Ensembl ID		ENSG00000254505	ENSG00000065883
Uniprot IDs		Q9BY43	A0A024RA66 A0A024RA85 Q14004 Q9BVE2
PDB IDs		3C3O 5MK1	5EFQ
Enriched GO Terms of Interacting Partners?
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