GIT1 and PCLO

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo, two hybrid)

		GIT1	PCLO
Description		GIT ArfGAP 1	piccolo presynaptic cytomatrix protein
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Cytosol Focal Adhesion Membrane Calyx Of Held	Cytoskeleton Postsynaptic Density Axon Synapse Cytoskeleton Of Presynaptic Active Zone Extracellular Exosome Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	GTPase Activator Activity Protein Binding Protein-containing Complex Binding Metal Ion Binding	Calcium Ion Binding Profilin Binding Calcium-dependent Phospholipid Binding Structural Constituent Of Presynaptic Active Zone
	Biological Process	Intramembranous Ossification Brain Development Locomotory Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Cytokinesis Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of GTPase Activity Cell Redox Homeostasis Negative Regulation Of Glycolytic Process Ephrin Receptor Signaling Pathway Neuron Development Motor Learning Cellular Response To Lipopolysaccharide Presynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Inflammatory Response To Wounding Regulation Of Synaptic Vesicle Exocytosis	Cytoskeleton Organization Synaptic Vesicle Exocytosis Regulation Of Exocytosis CAMP-mediated Signaling Insulin Secretion Protein Localization To Synapse Maintenance Of Presynaptic Active Zone Structure Synaptic Vesicle Clustering Presynapse To Nucleus Signaling Pathway Presynaptic Active Zone Assembly
Pathways		Ephrin signaling Ephrin signaling Activation of RAC1 downstream of NMDARs
Drugs
Diseases
GWAS		Adult body size ( 32376654) Brain morphology (MOSTest) ( 32665545)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Depressive symptoms x independent stressful life events interaction (1df test) ( 30718454) Energy expenditure (24h) ( 28476931) Grapefruit juice consumption ( 31046077) Major depressive disorder ( 21621269 28540843 20351715) Metabolite levels ( 23823483) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Refractive error ( 32231278) Rosacea symptom severity ( 29771307)
Interacting Genes		52 interacting genes: ARHGEF6 ARHGEF7 BARD1 C8orf33 CCDC113 CDC42 CENPU CEP126 CHD3 DDX24 EIF6 ENTR1 GIT2 GRB2 GRK2 GRK3 GRK5 GRK6 HAP1 HMOX2 HTT KIF1A LAMTOR5 LPXN LRIF1 MAN2A2 NEK2 PAK3 PCLO PDPK1 PFDN1 PLCG1 PMF1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PTK2 PTPRZ1 PXN RAN RGS2 RIF1 SRC SRRT TAB1 TERF1 TGFB1I1 TRIB3 TXNDC9 WDR33 YWHAG	4 interacting genes: ERC2 GIT1 GIT2 PCAT1
Entrez ID		28964	27445
HPRD ID		06577	16078
Ensembl ID		ENSG00000108262	ENSG00000186472
Uniprot IDs		Q59FC3 Q9Y2X7	Q9Y6V0
PDB IDs			1UJD
Enriched GO Terms of Interacting Partners?
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