GRIA2 and GRIA3

Data Source:
HPRD (in vitro)

		GRIA2	GRIA3
Description		glutamate ionotropic receptor AMPA type subunit 2	glutamate ionotropic receptor AMPA type subunit 3
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Postsynaptic Density Dendrite Endocytic Vesicle Membrane Asymmetric Synapse AMPA Glutamate Receptor Complex Neuronal Cell Body Dendritic Spine Excitatory Synapse Postsynapse Postsynaptic Density Membrane Postsynaptic Endocytic Zone	Plasma Membrane Endocytic Vesicle Membrane AMPA Glutamate Receptor Complex Dendritic Spine Postsynaptic Membrane Parallel Fiber To Purkinje Cell Synapse
	Molecular Function	Amyloid-beta Binding Ionotropic Glutamate Receptor Activity AMPA Glutamate Receptor Activity Protein Binding Ligand-gated Ion Channel Activity Signaling Receptor Activity	Amyloid-beta Binding AMPA Glutamate Receptor Activity Ligand-gated Ion Channel Activity Signaling Receptor Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Signal Transduction Chemical Synaptic Transmission Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of NMDA Receptor Activity	Glutamate Receptor Signaling Pathway Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Postsynaptic Membrane Potential Regulation Of NMDA Receptor Activity
Pathways		Activation of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation MECP2 regulates neuronal receptors and channels Long-term potentiation	Activation of AMPA receptors Trafficking of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Synaptic adhesion-like molecules
Drugs		Glutamic acid Butabarbital Butalbital Talbutal Pentobarbital Secobarbital Metharbital Thiopental Primidone Methylphenobarbital Ethanol Phenobarbital Quinidine barbiturate Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Barbital Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione (S)-DES-ME-AMPA (S)-AMPA 2-Amino-3-(5-Tert-Butyl-3-(Phosphonomethoxy)-4-Isoxazolyl)Propionic Acid Iodo-Willardiine Fluoro-Willardiine Quisqualic acid (S)-2-Amino-3-(1,3,5,7-Pentahydro-2,4-Dioxo-Cyclopenta[E]Pyrimidin-1-Yl) Proionic Acid (2S)-2-Ammonio-3-[5-(2-methyl-2-propanyl)-3-oxido-1,2-oxazol-4-yl]propanoate FG-9041 Bromo-Willardiine Willardiine 2-Amino-3-(3-Hydroxy-7,8-Dihydro-6h-Cyclohepta[D]-4-Isoxazolyl)Propionic Acid Aniracetam THIO-ATPA Talampanel CX-717 N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dimethanesulfonamide 2,3,6A,7,8,9-HEXAHYDRO-11H-[1,4]DIOXINO[2,3-G]PYRROLO[2,1-B][1,3]BENZOXAZIN-11-ONE (3S)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (3R)-3-cyclopentyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide (3R)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide Fluciclovine (18F)	Glutamic acid Butabarbital Ethanol Lithium cation Aniracetam Talampanel CX-717 Fluciclovine (18F) Lithium citrate Lithium succinate Lithium carbonate
Diseases			Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Triglyceride levels x loop diuretics use interaction ( 31806883)	Mortality in sepsis ( 27639821)
Interacting Genes		13 interacting genes: DRD2 GAPDH GRIA3 GRIP2 GTF3C2 ITGB3 NSF PICK1 PRKCA SDCBP SPTAN1 SPTBN1 SQSTM1	11 interacting genes: ADRB2 GRIA2 GRIP1 GRIP2 GZMB LYN NSF PICK1 PPM1G SDCBP SQSTM1
Entrez ID		2891	2892
HPRD ID		04726	02378
Ensembl ID		ENSG00000120251	ENSG00000125675
Uniprot IDs		P42262	P42263 Q17R51 Q5XKG2
PDB IDs		2WJW 2WJX 2XHD 3R7X 3RN8 3RNN 3UA8 5H8S 5YBF 5YBG 5ZG0 5ZG1 5ZG2 5ZG3
Enriched GO Terms of Interacting Partners?
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