GRIA3 and PPM1G

Data Source:
HPRD (in vivo, in vitro)

		GRIA3	PPM1G
Description		glutamate ionotropic receptor AMPA type subunit 3	protein phosphatase, Mg2+/Mn2+ dependent 1G
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Endocytic Vesicle Membrane AMPA Glutamate Receptor Complex Dendritic Spine Postsynaptic Membrane Parallel Fiber To Purkinje Cell Synapse	Nucleus Nucleoplasm Cytoplasm Membrane
	Molecular Function	Amyloid-beta Binding AMPA Glutamate Receptor Activity Ligand-gated Ion Channel Activity Signaling Receptor Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Protein Serine/threonine Phosphatase Activity Magnesium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Glutamate Receptor Signaling Pathway Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Postsynaptic Membrane Potential Regulation Of NMDA Receptor Activity	Protein Dephosphorylation Cell Cycle Arrest Peptidyl-threonine Dephosphorylation
Pathways		Activation of AMPA receptors Trafficking of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Synaptic adhesion-like molecules
Drugs		Glutamic acid Butabarbital Ethanol Lithium cation Aniracetam Talampanel CX-717 Fluciclovine (18F) Lithium citrate Lithium succinate Lithium carbonate
Diseases		Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Mortality in sepsis ( 27639821)	Bone mineral density (total hip) ( 29883787) Creatinine levels ( 31015462) Crohn's disease ( 28067908) Hypertriglyceridemia ( 23505323) Inflammatory bowel disease ( 28067908) Non-oily fish consumption ( 32066663) Takayasu arteritis ( 25604533) Triglyceride levels ( 31928498)
Interacting Genes		11 interacting genes: ADRB2 GRIA2 GRIP1 GRIP2 GZMB LYN NSF PICK1 PPM1G SDCBP SQSTM1	10 interacting genes: FBXO38 GRIA3 H3-4 LRPAP1 MSL1 MTNR1B RPS6KA1 TERF1 TERF2 TERF2IP
Entrez ID		2892	5496
HPRD ID		02378	09237
Ensembl ID		ENSG00000125675	ENSG00000115241
Uniprot IDs		P42263 Q17R51 Q5XKG2	O15355 Q6IAU5
PDB IDs
Enriched GO Terms of Interacting Partners?
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