FFAR3 and TREX1

Data Source:
BioGRID (two hybrid)

		FFAR3	TREX1
Description		free fatty acid receptor 3	three prime repair exonuclease 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Nuclear Envelope Cytoplasm Endoplasmic Reticulum Membrane Cytosol Oligosaccharyltransferase Complex Protein-DNA Complex Nuclear Replication Fork
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Lipid Binding	Magnesium Ion Binding Double-stranded DNA Binding Single-stranded DNA Binding 3'-5'-exodeoxyribonuclease Activity DNA Binding, Bending 3'-5' Exonuclease Activity Exodeoxyribonuclease III Activity MutLalpha Complex Binding MutSalpha Complex Binding Adenyl Deoxyribonucleotide Binding Protein Homodimerization Activity Metal Ion Binding WW Domain Binding
	Biological Process	Mucosal Immune Response Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Inflammatory Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Norepinephrine Secretion Positive Regulation Of Chemokine Production Negative Regulation Of Blood Pressure Regulation Of Insulin Receptor Signaling Pathway Regulation Of Hormone Biosynthetic Process Cellular Response To Fatty Acid Regulation Of Peptide Hormone Secretion	DNA Catabolic Process, Exonucleolytic Blood Vessel Development Kidney Development Activation Of Immune Response Macrophage Activation Involved In Immune Response Lymphoid Progenitor Cell Differentiation Immune Response In Brain Or Nervous System Inflammatory Response To Antigenic Stimulus T Cell Antigen Processing And Presentation Regulation Of Immunoglobulin Production Heart Morphogenesis Heart Process Atrial Cardiac Muscle Tissue Development Generation Of Precursor Metabolites And Energy Regulation Of Glycolytic Process DNA Metabolic Process DNA Replication DNA Repair Mismatch Repair DNA Modification DNA Recombination Determination Of Adult Lifespan Regulation Of Fatty Acid Metabolic Process Transposition, RNA-mediated Regulation Of Type I Interferon Production DNA Duplex Unwinding Regulation Of Tumor Necrosis Factor Production Cellular Response To Reactive Oxygen Species Cellular Response To Interferon-beta CD86 Biosynthetic Process Apoptotic Cell Clearance Regulation Of Cellular Respiration Establishment Of Protein Localization Regulation Of Lipid Biosynthetic Process Regulation Of Inflammatory Response Regulation Of Catalytic Activity Protein Stabilization Regulation Of T Cell Activation Defense Response To Virus Type I Interferon Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Protein Complex Stability Cellular Response To Gamma Radiation Detection Of Stimulus Involved In Cell Cycle Checkpoint Detection Of DNA Damage Stimulus Involved In DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Cellular Response To Hydroxyurea Immune Complex Formation DNA Synthesis Involved In UV-damage Excision Repair Regulation Of Lysosome Organization
Pathways		G alpha (q) signalling events Free fatty acid receptors	Regulation by TREX1 IRF3-mediated induction of type I IFN
Drugs
Diseases			Familial chilblain lupus (FCL); Chilblain lupus erythematosus (CHLE) Aicardi-Goutieres Syndrome (AGS) Retinal vasculopathy with cerebral leukodystrophy (RVCL)
GWAS			Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Obesity-related traits ( 23251661) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		13 interacting genes: CD79A COMT CTXN3 EFNA5 LAT LTC4S SERINC1 SLC41A1 TEX264 TOMM6 TREX1 UNC93B1 YIPF1	46 interacting genes: AQP6 ATM ATR CD81 CHCHD2 CLDN22 CRB3 CYB561 CYSRT1 EBP ELOVL4 FAM174A FFAR3 FNDC9 GJA5 GKN1 GPR42 HSD17B13 IFNGR2 IFT20 JAGN1 KRTAP10-7 MCM7 MFSD14B MSH2 NBN PEX12 PRKDC PRND RELL1 RIBC2 RNASEK RPA1 SEC11C SET SLC10A6 SLC22A2 SLC7A14 TM4SF18 TMEM205 TMEM207 TMEM45B TMEM86B TMX2 UBQLN1 VKORC1
Entrez ID		2865	11277
HPRD ID		04823	09423
Ensembl ID		ENSG00000185897	ENSG00000213689
Uniprot IDs		A0A0K0PUW7 O14843	Q5TZT0 Q9NSU2
PDB IDs
Enriched GO Terms of Interacting Partners?
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