TREX1 and CD81

Data Source:
BioGRID (two hybrid)

		TREX1	CD81
Description		three prime repair exonuclease 1	CD81 molecule
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Cytoplasm Endoplasmic Reticulum Membrane Cytosol Oligosaccharyltransferase Complex Protein-DNA Complex Nuclear Replication Fork	Immunological Synapse Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Basal Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Vesicle Extracellular Exosome Tetraspanin-enriched Microdomain
	Molecular Function	Magnesium Ion Binding Double-stranded DNA Binding Single-stranded DNA Binding 3'-5'-exodeoxyribonuclease Activity DNA Binding, Bending 3'-5' Exonuclease Activity Exodeoxyribonuclease III Activity MutLalpha Complex Binding MutSalpha Complex Binding Adenyl Deoxyribonucleotide Binding Protein Homodimerization Activity Metal Ion Binding WW Domain Binding	Virus Receptor Activity Integrin Binding Protein Binding Cholesterol Binding MHC Class II Protein Complex Binding MHC Class II Protein Binding Transferrin Receptor Binding
	Biological Process	DNA Catabolic Process, Exonucleolytic Blood Vessel Development Kidney Development Activation Of Immune Response Macrophage Activation Involved In Immune Response Lymphoid Progenitor Cell Differentiation Immune Response In Brain Or Nervous System Inflammatory Response To Antigenic Stimulus T Cell Antigen Processing And Presentation Regulation Of Immunoglobulin Production Heart Morphogenesis Heart Process Atrial Cardiac Muscle Tissue Development Generation Of Precursor Metabolites And Energy Regulation Of Glycolytic Process DNA Metabolic Process DNA Replication DNA Repair Mismatch Repair DNA Modification DNA Recombination Determination Of Adult Lifespan Regulation Of Fatty Acid Metabolic Process Transposition, RNA-mediated Regulation Of Type I Interferon Production DNA Duplex Unwinding Regulation Of Tumor Necrosis Factor Production Cellular Response To Reactive Oxygen Species Cellular Response To Interferon-beta CD86 Biosynthetic Process Apoptotic Cell Clearance Regulation Of Cellular Respiration Establishment Of Protein Localization Regulation Of Lipid Biosynthetic Process Regulation Of Inflammatory Response Regulation Of Catalytic Activity Protein Stabilization Regulation Of T Cell Activation Defense Response To Virus Type I Interferon Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Protein Complex Stability Cellular Response To Gamma Radiation Detection Of Stimulus Involved In Cell Cycle Checkpoint Detection Of DNA Damage Stimulus Involved In DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Cellular Response To Hydroxyurea Immune Complex Formation DNA Synthesis Involved In UV-damage Excision Repair Regulation Of Lysosome Organization	Activation Of MAPK Activity Immunological Synapse Formation Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Inflammatory Response To Antigenic Stimulus Protein Localization Positive Regulation Of Cell Population Proliferation Myoblast Fusion Involved In Skeletal Muscle Regeneration Regulation Of Complement Activation Positive Regulation Of B Cell Proliferation Receptor Internalization Regulation Of Protein Stability Macrophage Fusion CD4-positive, Alpha-beta T Cell Costimulation Positive Regulation Of 1-phosphatidylinositol 4-kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Viral Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Protein Localization To Lysosome Positive Regulation Of Protein Exit From Endoplasmic Reticulum Cellular Response To Low-density Lipoprotein Particle Stimulus Protein Localization To Plasma Membrane Osteoclast Fusion Positive Regulation Of Receptor Clustering Positive Regulation Of Protein Catabolic Process In The Vacuole Regulation Of Macrophage Migration Positive Regulation Of Adaptive Immune Memory Response Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell
Pathways		Regulation by TREX1 IRF3-mediated induction of type I IFN	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Regulation of Complement cascade
Drugs
Diseases		Familial chilblain lupus (FCL); Chilblain lupus erythematosus (CHLE) Aicardi-Goutieres Syndrome (AGS) Retinal vasculopathy with cerebral leukodystrophy (RVCL)
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Obesity-related traits ( 23251661) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Malaria ( 31844061)
Interacting Genes		46 interacting genes: AQP6 ATM ATR CD81 CHCHD2 CLDN22 CRB3 CYB561 CYSRT1 EBP ELOVL4 FAM174A FFAR3 FNDC9 GJA5 GKN1 GPR42 HSD17B13 IFNGR2 IFT20 JAGN1 KRTAP10-7 MCM7 MFSD14B MSH2 NBN PEX12 PRKDC PRND RELL1 RIBC2 RNASEK RPA1 SEC11C SET SLC10A6 SLC22A2 SLC7A14 TM4SF18 TMEM205 TMEM207 TMEM45B TMEM86B TMX2 UBQLN1 VKORC1	58 interacting genes: ADRA1A ADRB2 AQP6 BDKRB2 BST2 CCR2 CCR9 CD19 CD9 CHRM4 CPLX4 CSNK2B DLG5 EBP ERGIC3 F2RL1 FAM209A GJA4 GLP1R GORAB GPR152 GPR35 GPX8 HNRNPD HRH1 HTR4 IFITM1 IGSF8 INO80B ITGA4 JAK3 KIT LBR LHFPL5 LMNA MC4R MCEE MRPS18B MYOC NEMP1 OXTR PDZK1IP1 PTGFRN RBBP6 RNF128 SAR1A SDHAF4 SHC1 SIRPA SLC26A6 STX1A THAP4 TMX2 TREX1 TSHR TSPAN4 VKORC1 ZBTB16
Entrez ID		11277	975
HPRD ID		09423	08924
Ensembl ID		ENSG00000213689	ENSG00000110651
Uniprot IDs		Q5TZT0 Q9NSU2	A0A024RCB7 E9PJK1 P60033
PDB IDs			1G8Q 1IV5 2AVZ 3X0E 5DFV 5DFW 5M2C 5M33 5M3D 5M3T 5M4R 5TCX 6EJG 6EJM 6EK2 6U9S
Enriched GO Terms of Interacting Partners?
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