HSPG2 and COL13A1

Data Source:
HPRD (in vitro)

		HSPG2	COL13A1
Description		heparan sulfate proteoglycan 2	collagen type XIII alpha 1 chain
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Golgi Lumen Plasma Membrane Focal Adhesion Lysosomal Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Plasma Membrane Protein Complex	Extracellular Region Collagen Trimer Collagen Type XIII Trimer Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Cell-cell Junction Extracellular Matrix Postsynaptic Membrane Collagen-containing Extracellular Matrix
	Molecular Function	Amyloid-beta Binding Calcium Ion Binding Protein Binding Protein C-terminus Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Low-density Lipoprotein Particle Receptor Binding	Extracellular Matrix Structural Constituent Protein Binding Heparin Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Retinoid Metabolic Process Angiogenesis Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Lipid Metabolic Process Receptor-mediated Endocytosis Inflammatory Response Brain Development Animal Organ Morphogenesis Tissue Development Negative Regulation Of Angiogenesis Cell Differentiation Extracellular Matrix Organization Cellular Protein Metabolic Process Circulatory System Development	Skeletal System Development Morphogenesis Of A Branching Structure Endochondral Ossification Cell-matrix Adhesion Cell Differentiation Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Notochord Development Cell-cell Adhesion
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Integrin cell surface interactions Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Non-integrin membrane-ECM interactions ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport Amyloid fiber formation	Collagen degradation Collagen biosynthesis and modifying enzymes Integrin cell surface interactions Collagen chain trimerization
Drugs		Palifermin
Diseases		Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
GWAS		Atrial fibrillation ( 30061737) Height ( 28552196) PR interval ( 32439900)	Adverse response to drug ( 30420678) Antidepressant treatment resistance (number of drugs prescribed) ( 30700811) Carboplatin disposition in epthelial ovarian cancer ( 29367611) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Early childhood aggressive behavior ( 26087016) Middle childhood and early adolescence aggressive behavior ( 26087016) Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Optic disc size ( 31809533) Parkinson's disease ( 23793441) PR interval ( 32439900) Response to fenofibrate (total cholesterol levels) ( 27002377) Ulcerative colitis ( 25082827) Upper eyelid morphology ( 29921221)
Interacting Genes		32 interacting genes: APP ATF7IP ATN1 BMP1 CACNA1A CCN2 COL13A1 ECM1 FBLN1 FBLN2 FBN1 FGF2 FGF7 FGFBP1 FN1 GFI1B GRN ITGA2 ITGB1 LAMA1 MTDH NID1 NID2 PDGFA PDGFB PRELP PRPF40A SPARC TCAP TTR UBC VWA1	7 interacting genes: FN1 HSPG2 ITGA1 MTDH NID1 NID2 SPARC
Entrez ID		3339	1305
HPRD ID		00804	00383
Ensembl ID		ENSG00000142798	ENSG00000197467
Uniprot IDs		P98160	Q5TAT6
PDB IDs		3SH4 3SH5
Enriched GO Terms of Interacting Partners?
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