GPI and PARP14

Data Source:
HPRD (in vivo)

		GPI	PARP14
Description		glucose-6-phosphate isomerase	poly(ADP-ribose) polymerase family member 14
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GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytosol Plasma Membrane Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Glucose-6-phosphate Isomerase Activity Cytokine Activity Protein Binding Growth Factor Activity Ubiquitin Protein Ligase Binding Monosaccharide Binding	Transcription Corepressor Activity NAD+ ADP-ribosyltransferase Activity Protein Binding Enzyme Binding Protein ADP-ribosylase Activity
	Biological Process	Positive Regulation Of Immunoglobulin Production Carbohydrate Metabolic Process Gluconeogenesis Glycolytic Process Humoral Immune Response Signal Transduction Hemostasis Positive Regulation Of Endothelial Cell Migration Neutrophil Degranulation Glucose 6-phosphate Metabolic Process Canonical Glycolysis	Protein ADP-ribosylation Negative Regulation Of Gene Expression Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Innate Immune Response Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Protein Poly-ADP-ribosylation Protein Mono-ADP-ribosylation Positive Regulation Of Interleukin-4-mediated Signaling Pathway
Pathways		TP53 Regulates Metabolic Genes Neutrophil degranulation Glycolysis Gluconeogenesis	Nicotinamide salvaging Maturation of nucleoprotein Maturation of nucleoprotein
Drugs		alpha-D-glucose 6-phosphate 6-phospho-D-gluconic acid 5-phospho-D-arabinohydroxamic acid D-glucitol 6-phosphate 5-Phosphoarabinonic Acid Glucose-6-Phosphate D-erythrose 4-phosphate Fructose-6-phosphate Copper Artenimol
Diseases		Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Mean corpuscular volume ( 32888494)
Interacting Genes		6 interacting genes: AMFR CSNK2A1 IGFBP3 LINC01554 PARP14 PCNA	2 interacting genes: GPI PARP10
Entrez ID		2821	54625
HPRD ID		01394	11421
Ensembl ID		ENSG00000105220	ENSG00000173193
Uniprot IDs		A0A2U3TZU2 B4DE36 P06744	Q460N5 Q8N546
PDB IDs		1IAT 1IRI 1JIQ 1JLH 1NUH 6XUH 6XUI	3GOY 3Q6Z 3Q71 3SE2 3SMI 3SMJ 3VFQ 4ABK 4ABL 4D86 4F1L 4F1Q 4PY4 5LXP 5LYH 5NQE 5O2D 5QHT 5QHU 5QHV 5QHW 5QHX 5QHY 5QHZ 5QI0 5QI1 5QI2 5QI3 5QI4 5QI5 5QI6 5QI7 5QI8 5QI9 5QIA 5V7T 5V7W 6FYM 6FZM 6G0W 7D2C
Enriched GO Terms of Interacting Partners?
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