GNGT1 and RHO

Data Source:
HPRD (in vivo)

		GNGT1	RHO
Description		G protein subunit gamma transducin 1	rhodopsin
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Inner Segment Heterotrimeric G-protein Complex Plasma Membrane G-protein Beta/gamma-subunit Complex Photoreceptor Disc Membrane	Golgi Membrane Photoreceptor Outer Segment Photoreceptor Inner Segment Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Integral Component Of Membrane Golgi-associated Vesicle Membrane Photoreceptor Outer Segment Membrane Ciliary Membrane Photoreceptor Inner Segment Membrane Sperm Midpiece Photoreceptor Disc Membrane Sperm Head Plasma Membrane
	Molecular Function	GTPase Activity Protein Binding G-protein Beta-subunit Binding	G Protein-coupled Receptor Activity 11-cis Retinal Binding Protein Binding G Protein-coupled Photoreceptor Activity Metal Ion Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Protein Localization Cardiac Muscle Cell Apoptotic Process Rhodopsin Mediated Signaling Pathway Eye Photoreceptor Cell Development Cellular Response To Hypoxia	Retinoid Metabolic Process Protein Phosphorylation G Protein-coupled Receptor Signaling Pathway Visual Perception Phototransduction Phototransduction, Visible Light Absorption Of Visible Light Rhodopsin Mediated Signaling Pathway Protein-chromophore Linkage Regulation Of Rhodopsin Mediated Signaling Pathway Thermotaxis Photoreceptor Cell Maintenance Detection Of Temperature Stimulus Involved In Thermoception Retina Development In Camera-type Eye Cellular Response To Light Stimulus
Pathways		Activation of G protein gated Potassium channels G-protein activation Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Olfactory Signaling Pathway ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	The canonical retinoid cycle in rods (twilight vision) Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade G alpha (i) signalling events Opsins VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
Drugs			Halothane N-Acetylmethionine 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine B-nonylglucoside Phosphonothreonine B-2-Octylglucoside Hexadecanal Palmitic Acid Heptane-1,2,3-Triol Dodecyldimethylamine N-oxide (Hydroxyethyloxy)Tri(Ethyloxy)Octane Heptyl 1-Thiohexopyranoside Dexfosfoserine
Diseases			Congenital stationary night blindness (CSNB), including: CSNB type 1 (CSNB1); CSNB type 2 (CSNB2); CSNB autosomal dominant (CSNBAD); Oguchi disease/ CSNB Oguchi type (CSNBO) Retinitis pigmentosa (RP) Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)
GWAS		Body mass index ( 28552196) Body size at age 10 ( 32376654) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Mosquito bite size ( 28199695) Resting heart rate ( 29769521 27798624) Taxane-induced peripheral neuropathy in breast cancer ( 29278617)	Diisocyanate-induced asthma ( 25918132) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		14 interacting genes: GNAS GNB1 GNB2 GNB4 GNB5 GORASP2 IKBKG MSANTD4 NAGA PDCL PLEKHB1 RHO UBXN4 ZNF277	12 interacting genes: ARR3 ARRB2 CD79A DERL1 GNGT1 GRK1 GRK2 GRK5 GRK6 PPP2CA PRKCA SAG
Entrez ID		2792	6010
HPRD ID		01805	01584
Ensembl ID		ENSG00000127928	ENSG00000163914
Uniprot IDs		P63211	P08100
PDB IDs			4ZWJ 5DGY 5W0P 6CMO
Enriched GO Terms of Interacting Partners?
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