RHO and GRK5

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		RHO	GRK5
Description		rhodopsin	G protein-coupled receptor kinase 5
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GO Annotations	Cellular Component	Golgi Membrane Photoreceptor Outer Segment Photoreceptor Inner Segment Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Integral Component Of Membrane Golgi-associated Vesicle Membrane Photoreceptor Outer Segment Membrane Ciliary Membrane Photoreceptor Inner Segment Membrane Sperm Midpiece Photoreceptor Disc Membrane Sperm Head Plasma Membrane	Cytoplasm Cytosol Plasma Membrane Nuclear Speck Nuclear Membrane
	Molecular Function	G Protein-coupled Receptor Activity 11-cis Retinal Binding Protein Binding G Protein-coupled Photoreceptor Activity Metal Ion Binding	Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Phospholipid Binding Beta-adrenergic Receptor Kinase Activity
	Biological Process	Retinoid Metabolic Process Protein Phosphorylation G Protein-coupled Receptor Signaling Pathway Visual Perception Phototransduction Phototransduction, Visible Light Absorption Of Visible Light Rhodopsin Mediated Signaling Pathway Protein-chromophore Linkage Regulation Of Rhodopsin Mediated Signaling Pathway Thermotaxis Photoreceptor Cell Maintenance Detection Of Temperature Stimulus Involved In Thermoception Retina Development In Camera-type Eye Cellular Response To Light Stimulus	Apoptotic Process G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Wnt Signaling Pathway Negative Regulation Of Apoptotic Process Protein Autophosphorylation Regulation Of Cell Cycle
Pathways		The canonical retinoid cycle in rods (twilight vision) Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade G alpha (i) signalling events Opsins VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium	G alpha (q) signalling events G alpha (s) signalling events
Drugs		Halothane N-Acetylmethionine 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine B-nonylglucoside Phosphonothreonine B-2-Octylglucoside Hexadecanal Palmitic Acid Heptane-1,2,3-Triol Dodecyldimethylamine N-oxide (Hydroxyethyloxy)Tri(Ethyloxy)Octane Heptyl 1-Thiohexopyranoside Dexfosfoserine
Diseases		Congenital stationary night blindness (CSNB), including: CSNB type 1 (CSNB1); CSNB type 2 (CSNB2); CSNB autosomal dominant (CSNBAD); Oguchi disease/ CSNB Oguchi type (CSNBO) Retinitis pigmentosa (RP) Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)
GWAS		Diisocyanate-induced asthma ( 25918132) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Coronary artery aneurysm in Kawasaki disease ( 27171184) Early onset periodontitis x smoking status interaction ( 31537151) Height ( 28552196) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494 27863252) Methadone dose in opioid dependence ( 30060048) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Risky sexual behaviors in alcohol dependence ( 28990359) Thrombin-induced platelet aggregation ( 32649856) Type 2 diabetes ( 22961080) Venous thromboembolism ( 31420334 31676865)
Interacting Genes		12 interacting genes: ARR3 ARRB2 CD79A DERL1 GNGT1 GRK1 GRK2 GRK5 GRK6 PPP2CA PRKCA SAG	19 interacting genes: ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CABP1 CALM1 CAV1 CHRM2 DLGAP2 GIT1 RCVRN RHO SNCA SNCB SNCG TACR1 TBXA2R
Entrez ID		6010	2869
HPRD ID		01584	02926
Ensembl ID		ENSG00000163914	ENSG00000198873
Uniprot IDs		P08100	P34947
PDB IDs		4ZWJ 5DGY 5W0P 6CMO	4TNB 4TND
Enriched GO Terms of Interacting Partners?
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