GNAZ and EYA1

Data Source:
HPRD (in vitro, two hybrid)

		GNAZ	EYA1
Description		G protein subunit alpha z	EYA transcriptional coactivator and phosphatase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Cytosol Heterotrimeric G-protein Complex Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Nuclear Body
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding Metal Ion Binding	Protein Tyrosine Phosphatase Activity Protein Binding Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Protein Folding G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway	Double-strand Break Repair Sensory Perception Of Sound Anatomical Structure Morphogenesis Response To Ionizing Radiation Histone Dephosphorylation Protein Sumoylation Cell Differentiation Peptidyl-tyrosine Dephosphorylation Ear Morphogenesis Positive Regulation Of DNA Repair Anatomical Structure Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		PLC beta mediated events PLC beta mediated events G-protein activation G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding ADORA2B mediated anti-inflammatory cytokines production	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases			Contiguous gene deletion syndrome involving EYA1, including: Oto-facio-cervical syndrome (OFC); Branchiootic syndrome 1 (BOS1); Branchio-oto-renal syndrome (BOR)
GWAS		Handedness (Left-handed vs. non-left-handed) ( 31504236) Handedness (left-handed vs. right-handed) ( 31504236) Height ( 18391951) Processed meat consumption ( 32066663)	Adolescent idiopathic scoliosis ( 30395268) Chin dimples ( 27182965) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Heel bone mineral density ( 30598549 28869591) Hypospadias ( 25108383) Longevity (85 years and older) ( 24688116) Paneth cell defects in Crohn's disease ( 28352666) Sleep-related phenotypes ( 17903308) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 28448500)
Interacting Genes		16 interacting genes: ADORA1 APP DRD2 DRD5 EYA1 EYA2 LRRK1 NMT1 NUCB1 OPRD1 PRKCD RAP1GAP RGS10 RGS19 RGS20 RGS7	8 interacting genes: DACH1 GNAI2 GNAZ GSK3B H2AX SIX1 SIX2 SIX3
Entrez ID		2781	2138
HPRD ID		00746	03388
Ensembl ID		ENSG00000128266	ENSG00000104313
Uniprot IDs		P19086 Q8IY73	A0A024R813 A0A2R8Y6K4 A6NCB9 B3KXR1 F8WB53 Q0P517 Q99502
PDB IDs
Enriched GO Terms of Interacting Partners?
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