GNAS and CYSLTR2

Data Source:
BioGRID (two hybrid)

		GNAS	CYSLTR2
Description		GNAS complex locus	cysteinyl leukotriene receptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Heterotrimeric G-protein Complex Membrane Apical Plasma Membrane Dendrite Extracellular Exosome	Cellular_component Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity Insulin-like Growth Factor Receptor Binding Protein Binding GTP Binding Adenylate Cyclase Activator Activity G-protein Beta/gamma-subunit Complex Binding Beta-2 Adrenergic Receptor Binding D1 Dopamine Receptor Binding Mu-type Opioid Receptor Binding Ionotropic Glutamate Receptor Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding	Cysteinyl Leukotriene Receptor Activity Leukotriene Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity
	Biological Process	Tissue Homeostasis Endochondral Ossification Energy Reserve Metabolic Process DNA Methylation Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Sensory Perception Of Chemical Stimulus Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Post-embryonic Body Morphogenesis Response To Drug Skin Development Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoclast Differentiation Developmental Growth Embryonic Cranial Skeleton Morphogenesis Regulation Of Catalytic Activity Cartilage Development Bone Development Platelet Aggregation Genetic Imprinting Positive Regulation Of Cold-induced Thermogenesis Regulation Of Parathyroid Hormone Secretion	Immune Response G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Leukotriene Signaling Pathway
Pathways		Glucagon signaling in metabolic regulation PKA activation in glucagon signalling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production Glucagon signaling in metabolic regulation PKA activation in glucagon signalling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production	Glucagon signaling in metabolic regulation Leukotriene receptors G alpha (q) signalling events G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production LTC4-CYSLTR mediated IL4 production
Drugs		Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE	Nedocromil Leukotriene C4 Leukotriene D4
Diseases		Fibrous dysplasia, polyostotic; Albright hereditary osteodystrophy Pseudohypoparathyroidism Progressive osseous heteroplasia (POH)
GWAS		Birth weight ( 31043758) Blood pressure ( 21909110) Blood urea nitrogen levels ( 31152163) Body size at age 10 ( 32376654) Colorectal cancer ( 30529582) Creatinine levels ( 29124443) Diastolic blood pressure ( 21909115 29403010 28739976 27618452 30487518) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) DNA methylation (variation) ( 23725790) Estimated glomerular filtration rate ( 31152163 31015462 29124443) HDL cholesterol levels ( 32203549) Height ( 31562340) Hypertension ( 21909115) Hyperuricemia ( 29124443) Mean arterial pressure ( 29403010) Platelet distribution width ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Renal function-related traits (BUN) ( 22797727) Response to diuretic therapy in hypertension ( 23753411) Serum uric acid levels ( 29124443) Sulfasalazine-induced agranulocytosis ( 28762467) Systolic blood pressure ( 21909115 28739976 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Type 2 diabetes ( 30297969 32499647) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 26785701)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382) Systemic juvenile idiopathic arthritis ( 27927641)
Interacting Genes		40 interacting genes: ADCY2 ADCY5 ADCY6 ADORA1 ADRB2 ADRB3 AVPR2 AXIN1 CALM1 CAV3 CHEK2 CHRM3 CRHR1 CYSLTR2 EGFR FZD7 GCGR GLP1R GNB1 GNGT1 HTR6 LHB LHCGR MSANTD3 MTNR1B NUCB1 NUCB2 OPTN PANX1 PTGDR PTGIR RGS2 RIC8A RIC8B RXFP3 SNX13 TBXA2R TSHR TTC1 VIPR1	19 interacting genes: ATP5MC2 DBI ENO1 GNAS GRIK1 HSP90B1 KRTAP1-1 LNX1 MTUS2 NCKIPSD PCDH9 PCMT1 RNASEK RNF144A RTN4 SVOP TTC19 YIPF6 YWHAE
Entrez ID		2778	57105
HPRD ID		00761	09293
Ensembl ID		ENSG00000087460	ENSG00000152207
Uniprot IDs		A0A0S2Z3H8 A0A0S2Z3S5 A0A590UJF0 B0AZR9 O95467 P63092 P84996 Q14455 Q5FWY2 Q5JWD1 Q5JWF2	A4ZKH2 Q5KU17 Q9NS75
PDB IDs		5G53 5UZ7 5VAI 6AU6 6B3J 6E3Y 6E67 6EG8 6GDG 6LI3 6LMK 6LPB 6M1H 6M1I 6NI3 6NIY 6ORV 6P9X 6P9Y 6PB0 6PB1 6UUN 6UUS 6UVA 6VCB 6VN7 6WHC 6WI9 6WPW 6WZG 6X18 6X19 6X1A 7BW0 7BZ2 7C2E 7CFM 7CFN 7D3S
Enriched GO Terms of Interacting Partners?
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