GLI3 and TAF9

Data Source:
BioGRID (pull down)

		GLI3	TAF9
Description		GLI family zinc finger 3	TATA-box binding protein associated factor 9
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cilium Axoneme Nuclear Speck Transcription Repressor Complex Intracellular Membrane-bounded Organelle Ciliary Tip Ciliary Base	SAGA Complex PCAF Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex STAGA Complex Transcription Factor TFTC Complex Pre-snoRNP Complex MLL1 Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Histone Acetyltransferase Binding Mediator Complex Binding Histone Deacetylase Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Transcription Regulatory Region Sequence-specific DNA Binding P53 Binding DNA Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Activating Transcription Factor Binding Protein Heterodimerization Activity ATPase Binding C2H2 Zinc Finger Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Metanephros Development Branching Involved In Ureteric Bud Morphogenesis In Utero Embryonic Development Positive Regulation Of Neuroblast Proliferation Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Axon Guidance Hindgut Morphogenesis Heart Development Negative Regulation Of Cell Population Proliferation Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Protein Processing Optic Nerve Morphogenesis Hippocampus Development Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Forebrain Dorsal/ventral Pattern Formation Layer Formation In Cerebral Cortex Forebrain Radial Glial Cell Differentiation Lateral Ganglionic Eminence Cell Proliferation Melanocyte Differentiation Lung Development Prostate Gland Development Positive Regulation Of Chondrocyte Differentiation T Cell Differentiation In Thymus Limb Morphogenesis Wound Healing Positive Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Nose Morphogenesis Tongue Development Response To Estrogen Negative Thymic T Cell Selection Negative Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Differentiation Embryonic Digestive Tract Morphogenesis Embryonic Digestive Tract Development Developmental Growth Camera-type Eye Morphogenesis Embryonic Neurocranium Morphogenesis Oligodendrocyte Differentiation Roof Of Mouth Development Frontal Suture Morphogenesis Lambdoid Suture Morphogenesis Sagittal Suture Morphogenesis Mammary Gland Specification Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Artery Development Anterior Semicircular Canal Development Lateral Semicircular Canal Development Cell Differentiation Involved In Kidney Development Thymocyte Apoptotic Process Vocalization Behavior Negative Regulation Of Canonical Wnt Signaling Pathway Liver Regeneration Larynx Morphogenesis Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Regulation Of Bone Development	Box C/D SnoRNP Assembly Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process SnRNA Transcription By RNA Polymerase II Negative Regulation Of Apoptotic Process Histone H3 Acetylation Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Positive Regulation Of Response To Cytokine Stimulus Response To Interleukin-1 Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Pathways		GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state Hedgehog 'on' state GLI proteins bind promoters of Hh responsive genes to promote transcription RUNX2 regulates osteoblast differentiation	HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome HATs acetylate histones RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance
Drugs
Diseases		Pallister-Hall syndrome Acrocallosal syndrome; Greig cephalopolysyndactyly syndrome
GWAS		Age-related macular degeneration ( 23326517) Allergic rhinitis ( 22036096) Asthma ( 29273806) Dietary fat liking ( 32516399) Digit length ratio ( 29659830) Digit length ratio (left hand) ( 29659830) Digit length ratio (right hand) ( 29659830) Emotional recognition ( 31596458) facial morphology traits (multivariate analysis) ( 27193062) Health literacy ( 31250787) Language performance in older adults (adjusted for episodic memory) ( 28577822) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Metabolite levels ( 23823483) middle facial morphology traits (quantitative measurement) ( 27193062) Refractive error ( 32231278)
Interacting Genes		19 interacting genes: BTRC CREBBP CSNK1A1 GSK3A MED12 PRKCA RHOU SKI SMAD1 SMAD2 SMAD3 SMAD4 STK36 SUFU TAF9 TWIST1 ZIC1 ZIC2 ZIC3	57 interacting genes: AHR ANK2 APP CEBPB CIITA COIL DRAP1 EEF1A1 ELF3 FBL FBLN1 FEZ1 GALNT6 GLI1 GLI2 GLI3 GTF2B H3-4 HCFC1 HNF4A HSF1 KLF6 KMT2A KPNA1 KPNA6 LAMTOR5 MAGEC2 MYC NCOA2 NCOR1 NDRG1 NFATC2 NR1D2 NUFIP1 PJA1 RBM48 RELA RNF138 RPS14 RPS24 RUVBL1 RUVBL2 SF3B3 TAF1 TAF10 TAF11 TAF12 TAF2 TAF4 TAF5 TAF6 TAF6L TAF7 TAF8 TBCA TP53 UBA1
Entrez ID		2737	6880
HPRD ID		01313	15983
Ensembl ID		ENSG00000106571	ENSG00000273841
Uniprot IDs		A0A2R8YGX0 P10071	Q16594
PDB IDs		4BLD	6F3T 6MZC 6MZD 6MZL 6MZM
Enriched GO Terms of Interacting Partners?
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