BMP10 and CD33

Data Source:
BioGRID (two hybrid)

		BMP10	CD33
Description		bone morphogenetic protein 10	CD33 molecule
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cell Surface Z Disc	Nucleoplasm Peroxisome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Specific Granule Membrane Tertiary Granule Membrane
	Molecular Function	Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Telethonin Binding Receptor Serine/threonine Kinase Binding	Protein Binding Protein Phosphatase Binding Carbohydrate Binding Sialic Acid Binding Signaling Receptor Activity
	Biological Process	Kidney Development Cell Adhesion Adult Heart Development Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration BMP Signaling Pathway Activin Receptor Signaling Pathway Sarcomere Organization Positive Regulation Of Transcription, DNA-templated Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Sarcomere Organization Heart Trabecula Formation Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis	Immune Response-inhibiting Signal Transduction Cell Adhesion Signal Transduction Cell-cell Signaling Negative Regulation Of Cell Population Proliferation Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Neutrophil Degranulation Positive Regulation Of Protein Secretion Regulation Of Immune Response Negative Regulation Of Calcium Ion Transport Cell-cell Adhesion Negative Regulation Of Monocyte Activation Positive Regulation Of Protein Tyrosine Phosphatase Activity
Pathways		Signaling by BMP Molecules associated with elastic fibres	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation
Drugs			Gemtuzumab ozogamicin AVE9633
Diseases
GWAS			Alzheimer's disease ( 18976728 31473137) Alzheimer's disease (late onset) ( 21460841 30617256 24162737 28714976) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Basophil count ( 32888494) Blood protein levels ( 30072576 29875488 28240269) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Eosinophil counts ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) HIV-1 susceptibility ( 25786224) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Triacylglyceride levels ( 31551469) White blood cell count ( 32888494 27863252)
Interacting Genes		59 interacting genes: ACVR2A ACVR2B APOA5 AQP6 ARL13B BIK BMPR2 BSCL2 BSND CCDC70 CD33 CISD2 CLDN7 COQ9 CREB3L1 DEXI EBP ERP29 FAM209A FCGR1A FCRL4 FFAR2 FKBP7 FNDC9 GGT6 GJB1 GPR152 GPX8 IL3RA JAGN1 KIR2DL3 KIR3DL1 KLRC1 LRRC25 LRRC4C MGST3 MRPS18B MS4A3 MTIF3 PLPP4 REEP4 SERINC3 SIT1 SLC10A1 SLC10A6 SLC35C2 SLC38A1 SLC4A1 SPAG4 TCTA TMEM14B TMEM31 TMEM45B TMEM86B TMPRSS2 TNFSF14 TNFSF8 TSPAN31 VSIR	21 interacting genes: BMP10 C3orf52 CXCL9 CYB5B EMD GIMAP5 HERC3 KRT31 KRT35 KRT40 PTPN11 PTPN6 RPRM SCD SRC THSD7A TMBIM1 TMEM100 TMEM243 TNMD UBIAD1
Entrez ID		27302	945
HPRD ID		09788	01165
Ensembl ID		ENSG00000163217	ENSG00000105383
Uniprot IDs		O95393	P20138 Q546G0
PDB IDs		6SF1 6SF3	5IHB 5J06 5J0B 6D48 6D49 6D4A 6TL8
Enriched GO Terms of Interacting Partners?
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