RNF115 and CDK10

Data Source:
BioGRID (two hybrid)

		RNF115	CDK10
Description		ring finger protein 115	cyclin dependent kinase 10
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleus Cytoplasm Ciliary Basal Body
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Protein Polyubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination	Protein Phosphorylation Traversing Start Control Point Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Population Proliferation Peptidyl-threonine Phosphorylation Cell Projection Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of MAPK Cascade Negative Regulation Of Cilium Assembly
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Breast cancer ( 25751625 29059683) HDL cholesterol levels ( 32203549) Platelet distribution width ( 32888494)	Blond vs. brown/black hair color ( 30531825) Brain morphology (MOSTest) ( 32665545) Brown vs. black hair color ( 30531825) Cutaneous malignant melanoma ( 32341527) Height ( 25429064) Hemoglobin levels ( 32327693) Intake of total sugars ( 31005972) Melanoma ( 28212542) Red vs. brown/black hair color ( 30531825)
Interacting Genes		32 interacting genes: AKT1 APP ATN1 CDK10 CST3 DAZAP2 DOCK4 EGFR FOLR3 HRAS IGHA1 MDM4 MFAP4 NFKBIA RAB7A RAD23A RPL18A TTR UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2N UBE2W USP9X VCP ZNRD2	4 interacting genes: CCR4 ETS2 FBXO7 RNF115
Entrez ID		27246	8558
HPRD ID		18328	04588
Ensembl ID		ENSG00000265491	ENSG00000185324
Uniprot IDs		Q9Y4L5	B7Z537 Q15131
PDB IDs
Enriched GO Terms of Interacting Partners?
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