RNF115 and IGHA1

Data Source:
BioGRID (two hybrid)

		RNF115	IGHA1
Description		ring finger protein 115	immunoglobulin heavy constant alpha 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol	Extracellular Region Extracellular Space External Side Of Plasma Membrane Immunoglobulin Complex, Circulating Extracellular Exosome Monomeric IgA Immunoglobulin Complex Secretory IgA Immunoglobulin Complex Secretory Dimeric IgA Immunoglobulin Complex Blood Microparticle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Antigen Binding Immunoglobulin Receptor Binding
	Biological Process	Protein Polyubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination	Retina Homeostasis Glomerular Filtration Receptor-mediated Endocytosis Phagocytosis, Recognition Phagocytosis, Engulfment Immune Response Complement Activation, Classical Pathway Protein-chromophore Linkage Antibacterial Humoral Response Defense Response To Bacterium Innate Immune Response B Cell Receptor Signaling Pathway Positive Regulation Of B Cell Activation Leukocyte Migration Positive Regulation Of Respiratory Burst
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Breast cancer ( 25751625 29059683) HDL cholesterol levels ( 32203549) Platelet distribution width ( 32888494)	Composite immunoglobulin trait (IgA/IgG) ( 28628107) Composite immunoglobulin trait (IgA/IgM) ( 28628107)
Interacting Genes		32 interacting genes: AKT1 APP ATN1 CDK10 CST3 DAZAP2 DOCK4 EGFR FOLR3 HRAS IGHA1 MDM4 MFAP4 NFKBIA RAB7A RAD23A RPL18A TTR UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2N UBE2W USP9X VCP ZNRD2	3 interacting genes: FYN LYN RNF115
Entrez ID		27246	3493
HPRD ID		18328
Ensembl ID		ENSG00000265491	ENSG00000211895
Uniprot IDs		Q9Y4L5
PDB IDs
Enriched GO Terms of Interacting Partners?
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