GCH1 and BDH1

Data Source:
BioGRID (affinity chromatography technology)

		GCH1	BDH1
Description		GTP cyclohydrolase 1	3-hydroxybutyrate dehydrogenase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein-containing Complex Neuron Projection Terminus	Mitochondrion Mitochondrial Matrix Matrix Side Of Mitochondrial Inner Membrane
	Molecular Function	GTPase Activity GTP Cyclohydrolase I Activity Calcium Ion Binding Protein Binding GTP Binding Zinc Ion Binding GTP-dependent Protein Binding Translation Initiation Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Mitogen-activated Protein Kinase Binding	3-hydroxybutyrate Dehydrogenase Activity
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Regulation Of Blood Pressure Positive Regulation Of Heart Rate Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Interferon-gamma Response To Tumor Necrosis Factor 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Vasodilation Dopamine Biosynthetic Process Pteridine-containing Compound Biosynthetic Process Negative Regulation Of Blood Pressure Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Positive Regulation Of Nitric-oxide Synthase Activity Protein-containing Complex Assembly Regulation Of Removal Of Superoxide Radicals	Ketone Body Biosynthetic Process Ketone Body Catabolic Process
Pathways		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	Utilization of Ketone Bodies Synthesis of Ketone Bodies
Drugs		Guanine	NADH
Diseases		Primary torsion dystonia (PTD) Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Chronotype ( 30696823) Mercury levels ( 26025379) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Parkinson's disease ( 25064009 32201043 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 22446963)	Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Frontotemporal dementia with GRN mutation ( 29724592) Waist-hip ratio ( 28552196)
Interacting Genes		15 interacting genes: AHSA1 ATP1B1 CDC37 CNRIP1 GCHFR GIT2 HSPA8 RAB26 RLF RPH3A SH3GL2 SP3 TNPO2 TNPO3 YWHAZ	1 interacting genes: APP
Entrez ID		2643	622
HPRD ID		02573	04344
Ensembl ID		ENSG00000131979	ENSG00000161267
Uniprot IDs		A0A024R642 P30793 Q8IZH9	A0A384MTY4 Q02338
PDB IDs		1FB1
Enriched GO Terms of Interacting Partners?
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