GCH1 and RAB26

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GCH1	RAB26
Description		GTP cyclohydrolase 1	RAB26, member RAS oncogene family
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein-containing Complex Neuron Projection Terminus	Golgi Membrane Endosome Golgi Apparatus Secretory Granule Membrane Intrinsic Component Of Plasma Membrane Anchored Component Of Synaptic Vesicle Membrane
	Molecular Function	GTPase Activity GTP Cyclohydrolase I Activity Calcium Ion Binding Protein Binding GTP Binding Zinc Ion Binding GTP-dependent Protein Binding Translation Initiation Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Mitogen-activated Protein Kinase Binding	GTPase Activity Protein Binding GTP Binding GMP Binding
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Regulation Of Blood Pressure Positive Regulation Of Heart Rate Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Interferon-gamma Response To Tumor Necrosis Factor 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Vasodilation Dopamine Biosynthetic Process Pteridine-containing Compound Biosynthetic Process Negative Regulation Of Blood Pressure Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Positive Regulation Of Nitric-oxide Synthase Activity Protein-containing Complex Assembly Regulation Of Removal Of Superoxide Radicals	Regulation Of Exocytosis Exocrine System Development Golgi To Plasma Membrane Protein Transport Regulated Exocytosis Regulation Of Protein Catabolic Process At Presynapse, Modulating Synaptic Transmission
Pathways		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	RAB geranylgeranylation
Drugs		Guanine
Diseases		Primary torsion dystonia (PTD) Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Chronotype ( 30696823) Mercury levels ( 26025379) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Parkinson's disease ( 25064009 32201043 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 22446963)
Interacting Genes		15 interacting genes: AHSA1 ATP1B1 CDC37 CNRIP1 GCHFR GIT2 HSPA8 RAB26 RLF RPH3A SH3GL2 SP3 TNPO2 TNPO3 YWHAZ	7 interacting genes: APP FHL5 GCH1 KRT33B OIP5 RIMS1 UNKL
Entrez ID		2643	25837
HPRD ID		02573	05676
Ensembl ID		ENSG00000131979	ENSG00000167964
Uniprot IDs		A0A024R642 P30793 Q8IZH9	Q9ULW5
PDB IDs		1FB1	2G6B
Enriched GO Terms of Interacting Partners?
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