GCH1 and GCHFR

Data Source:
HPRD (in vitro)

		GCH1	GCHFR
Description		GTP cyclohydrolase 1	GTP cyclohydrolase I feedback regulator
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein-containing Complex Neuron Projection Terminus	Nucleus Nucleoplasm Cytoplasm Cytosol Dendrite Nuclear Membrane Protein-containing Complex Melanosome
	Molecular Function	GTPase Activity GTP Cyclohydrolase I Activity Calcium Ion Binding Protein Binding GTP Binding Zinc Ion Binding GTP-dependent Protein Binding Translation Initiation Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Mitogen-activated Protein Kinase Binding	Enzyme Inhibitor Activity Protein Binding Amino Acid Binding GTP-dependent Protein Binding GTP Cyclohydrolase Binding Protein-containing Complex Binding
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Regulation Of Blood Pressure Positive Regulation Of Heart Rate Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Interferon-gamma Response To Tumor Necrosis Factor 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Vasodilation Dopamine Biosynthetic Process Pteridine-containing Compound Biosynthetic Process Negative Regulation Of Blood Pressure Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Positive Regulation Of Nitric-oxide Synthase Activity Protein-containing Complex Assembly Regulation Of Removal Of Superoxide Radicals	Nitric Oxide Biosynthetic Process Negative Regulation Of Biosynthetic Process Neurotransmitter Metabolic Process Negative Regulation Of GTP Cyclohydrolase I Activity Protein-containing Complex Assembly
Pathways		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs		Guanine
Diseases		Primary torsion dystonia (PTD) Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Chronotype ( 30696823) Mercury levels ( 26025379) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Parkinson's disease ( 25064009 32201043 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 22446963)	Anxiety and stress-related disorders ( 31116379) Malaria ( 31844061) Triglycerides ( 30275531)
Interacting Genes		15 interacting genes: AHSA1 ATP1B1 CDC37 CNRIP1 GCHFR GIT2 HSPA8 RAB26 RLF RPH3A SH3GL2 SP3 TNPO2 TNPO3 YWHAZ	1 interacting genes: GCH1
Entrez ID		2643	2644
HPRD ID		02573	03895
Ensembl ID		ENSG00000131979	ENSG00000137880
Uniprot IDs		A0A024R642 P30793 Q8IZH9	P30047
PDB IDs		1FB1
Enriched GO Terms of Interacting Partners?
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