GCH1 and OAZ1

Data Source:
BioGRID (affinity chromatography technology)

		GCH1	OAZ1
Description		GTP cyclohydrolase 1	ornithine decarboxylase antizyme 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein-containing Complex Neuron Projection Terminus	Nucleus Cytoplasm Cytosol
	Molecular Function	GTPase Activity GTP Cyclohydrolase I Activity Calcium Ion Binding Protein Binding GTP Binding Zinc Ion Binding GTP-dependent Protein Binding Translation Initiation Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Mitogen-activated Protein Kinase Binding	Protein Binding Ornithine Decarboxylase Inhibitor Activity
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Regulation Of Blood Pressure Positive Regulation Of Heart Rate Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Interferon-gamma Response To Tumor Necrosis Factor 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Vasodilation Dopamine Biosynthetic Process Pteridine-containing Compound Biosynthetic Process Negative Regulation Of Blood Pressure Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Positive Regulation Of Nitric-oxide Synthase Activity Protein-containing Complex Assembly Regulation Of Removal Of Superoxide Radicals	Regulation Of Cellular Amino Acid Metabolic Process Polyamine Biosynthetic Process Negative Regulation Of Catalytic Activity Positive Regulation Of Protein Catabolic Process Positive Regulation Of Intracellular Protein Transport Negative Regulation Of Polyamine Transmembrane Transport
Pathways		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	Regulation of ornithine decarboxylase (ODC)
Drugs		Guanine	Ornithine
Diseases		Primary torsion dystonia (PTD) Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Chronotype ( 30696823) Mercury levels ( 26025379) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Parkinson's disease ( 25064009 32201043 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 22446963)
Interacting Genes		15 interacting genes: AHSA1 ATP1B1 CDC37 CNRIP1 GCHFR GIT2 HSPA8 RAB26 RLF RPH3A SH3GL2 SP3 TNPO2 TNPO3 YWHAZ	11 interacting genes: AGTR1 ATXN1 EGFR HTR2B NLGN3 OAZ2 OAZ3 ODC1 PIAS4 PSMB4 SMAD1
Entrez ID		2643	4946
HPRD ID		02573	03346
Ensembl ID		ENSG00000131979	ENSG00000104904
Uniprot IDs		A0A024R642 P30793 Q8IZH9	J3QQY4 P54368
PDB IDs		1FB1	4ZGY 4ZGZ 5BWA
Enriched GO Terms of Interacting Partners?
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