PRPF31 and NCKIPSD

Data Source:
BioGRID (two hybrid)

		PRPF31	NCKIPSD
Description		pre-mRNA processing factor 31	NCK interacting protein with SH3 domain
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GO Annotations	Cellular Component	Nucleus Nucleoplasm U2-type Spliceosomal Complex U4 SnRNP U4atac SnRNP Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome MLL1 Complex Spliceosomal Tri-snRNP Complex	Cytosol Intermediate Filament COP9 Signalosome
	Molecular Function	RNA Binding Protein Binding U4 SnRNA Binding U4atac SnRNA Binding Identical Protein Binding Ribonucleoprotein Complex Binding SnRNP Binding	Protein Binding Cytoskeletal Protein Binding SH3 Domain Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly MRNA Splicing, Via Spliceosome SnoRNA Localization Ribonucleoprotein Complex Localization	Cytoskeleton Organization Positive Regulation Of Neuron Projection Development Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Pathways		mRNA Splicing - Major Pathway	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases		Retinitis pigmentosa (RP)
GWAS		Change in HbA1c levels in response to metformin treatment in type 2 diabetes ( 29650774)	Anorexia nervosa ( 31308545) Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Parkinson's disease ( 28892059) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		135 interacting genes: ASB15 BHLHB9 BICD2 C1QTNF1 CALCOCO2 CAPNS2 CARD14 CBY2 CCDC106 CCDC136 CCDC33 CCDC57 CCDC70 CCNDBP1 CDC23 CDCA7L CDR2L CEP70 CYSRT1 DVL2 DVL3 EFEMP2 EVI5 FANCA FANCC FASTK FLACC1 FSD2 FXR1 GOLGA2 GOLGA6L9 HAP1 HES7 HNRNPH2 HNRNPK HOOK2 HSF2BP JAKMIP2 KANK2 KCTD6 KHDRBS2 KHDRBS3 KIFC3 KRT15 KRT31 KRT34 KRT35 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-8 KRTAP10-9 KRTAP19-5 KRTAP4-11 KRTAP6-3 LBX1 LDOC1 LHX8 LURAP1 LZTS2 MDFI MEIS3 MEOX2 MID2 MIPOL1 MKRN3 MTUS2 NCAPH2 NCKIPSD NOTCH2NLA PAK5 PDE4DIP PHC2 PHF5A PICK1 PLEKHG4 PNMA1 PNMA2 PNMA3 PPIH PPP1R16A PPP2R3C PRDM14 PRICKLE1 PRPF3 PSTPIP1 RACK1 RBAK RBM25 RBM4 RBMX RBMY1A1 RBMY1F RBMY1J REL RINT1 RUNDC3A SIAH1 SLAIN1 SNRNP200 SRSF3 SSX2IP STX11 TADA2A TFIP11 TLE5 TMCC2 TP53BP2 TRIM14 TRIM23 TRIM27 TRIM41 TSGA10 UBXN11 USH1G USP15 VWC2 ZFP64 ZFP69B ZNF24 ZNF250 ZNF408 ZNF417 ZNF473 ZNF48 ZNF587 ZNF668 ZNF71 ZNF774 ZNF792 ZNF837 ZRANB1 ZSCAN22	41 interacting genes: ABI2 ARHGEF7 BAIAP2 CCDC187 CPNE2 CYSLTR2 DIAPH2 DIAPH3 DLG4 DMRTB1 ENKD1 FASLG GAS7 GRB2 HSPB1 ITGB1 KHDRBS1 LGALS4 MAPK3 MED25 NCK1 NCK2 PIN1 PKP2 POLR3C PRPF31 PSMD9 PSORS1C2 RBM22 RBP7 RXFP3 SNRPC SORBS3 STAC TSEN54 VEZF1 WAS WASL YWHAG ZBTB47 ZC2HC1C
Entrez ID		26121	51517
HPRD ID		05917	09450
Ensembl ID		ENSG00000105618	ENSG00000213672
Uniprot IDs		Q8WWY3	Q9NZQ3
PDB IDs		2OZB 3JCR 3SIU 3SIV 5O9Z 6AH0 6AHD 6QW6 6QX9	6DEC 6DED 6DEE
Enriched GO Terms of Interacting Partners?
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