LTN1 and STING1

Data Source:
BioGRID (pull down)

		LTN1	STING1
Description		listerin E3 ubiquitin protein ligase 1	stimulator of interferon response cGAMP interactor 1
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GO Annotations	Cellular Component	Cytosol RQC Complex	Autophagosome Membrane Nucleoplasm Mitochondrial Outer Membrane Endosome Autophagosome Peroxisome Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Integral Component Of Endoplasmic Reticulum Membrane Cytoplasmic Vesicle Membrane Secretory Granule Membrane Perinuclear Region Of Cytoplasm Integral Component Of Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Ribosomal Large Subunit Binding Ubiquitin Protein Ligase Activity	Protein Binding Transcription Factor Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Cyclic-di-GMP Binding Identical Protein Binding Protein Homodimerization Activity Cyclic-GMP-AMP Binding
	Biological Process	Protein Autoubiquitination Rescue Of Stalled Ribosome Ribosome-associated Ubiquitin-dependent Protein Catabolic Process	Autophagosome Assembly Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Viral Process Positive Regulation Of Macroautophagy Positive Regulation Of Protein Binding Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Interferon-beta Production Cellular Response To Interferon-beta Neutrophil Degranulation Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Positive Regulation Of DNA-binding Transcription Factor Activity Protein Complex Oligomerization Defense Response To Virus Reticulophagy Cellular Response To Exogenous DsRNA Cellular Response To Organic Cyclic Compound
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA STAT6-mediated induction of chemokines IRF3-mediated induction of type I IFN Neutrophil degranulation
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Hip circumference ( 28552196) Immature fraction of reticulocytes ( 32888494) Initial pursuit acceleration in psychotic disorders ( 29064472) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		8 interacting genes: HES4 IRF7 STING1 TIRAP UBC UBE2D1 UBE2D2 UBE2L3	22 interacting genes: CCDC47 CMTM5 DDOST IRAK1 LEPROTL1 LTN1 MBOAT7 MUL1 PLLP REEP6 RNF26 SGPL1 SMIM1 STT3A STX5 SURF4 TECR TMEM100 TRIM32 USP20 USP49 YIPF2
Entrez ID		26046	340061
HPRD ID		10327	14173
Ensembl ID		ENSG00000198862	ENSG00000184584
Uniprot IDs		O94822	J3QTB1 Q86WV6 V5V0K2
PDB IDs		3J92	4EF4 4EF5 4EMT 4EMU 4F5D 4F5E 4F5W 4F5Y 4F9E 4F9G 4KSY 4LOH 4LOI 4QXO 4QXP 4QXQ 4QXR 5BQX 5JEJ 6CFF 6CY7 6DNK 6DXG 6DXL 6MX0 6MX3 6MXE 6NT5 6O8B 6O8C 6RM0 6S26 6S27 6S86 6UKM 6UKU 6UKV 6UKW 6UKX 6UKY 6UKZ 6UL0 6XNP
Enriched GO Terms of Interacting Partners?
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