OSBPL3 and SYTL4

Data Source:
BioGRID (two hybrid)

		OSBPL3	SYTL4
Description		oxysterol binding protein like 3	synaptotagmin like 4
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Nuclear Membrane Filopodium Tip Intracellular Membrane-bounded Organelle Perinuclear Endoplasmic Reticulum	Endosome Plasma Membrane Extrinsic Component Of Membrane Transport Vesicle Membrane Platelet Alpha Granule Membrane Exocytic Vesicle
	Molecular Function	Protein Binding Sterol Transporter Activity Cholesterol Binding Sterol Binding	Protein Binding Phospholipid Binding Neurexin Family Protein Binding Metal Ion Binding
	Biological Process	Bile Acid Biosynthetic Process Sterol Transport	Plasma Membrane Repair Platelet Degranulation Intracellular Protein Transport Exocytosis Lysosome Localization Positive Regulation Of Exocytosis Negative Regulation Of Insulin Secretion Positive Regulation Of Protein Secretion Multivesicular Body Sorting Pathway Regulation Of Plasma Membrane Repair
Pathways		Synthesis of bile acids and bile salts	Platelet degranulation
Drugs			Insulin pork
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Pursuit maintenance gain ( 29064472) Sulfasalazine-induced agranulocytosis ( 28762467)	Lean body mass ( 28552196) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494)
Interacting Genes		25 interacting genes: ACSM1 BYSL FAM161A GABARAPL1 GABARAPL2 LNX1 MCRS1 PLK4 PRPF18 PRPF3 RALGPS2 RPL11 STK35 SYTL4 TCEA2 TCEANC TRAF3IP3 WT1 YWHAB YWHAG ZBTB16 ZNF48 ZNF497 ZNF648 ZNF835	27 interacting genes: CCDC85B CEP70 DVL3 FCHO1 FXR2 HMG20A INS KIFC3 LMO1 LZTS1 OSBPL3 PRKAR1B RAB27A RAB27B RAB3A RAB3D RAB8A ROPN1 SPANXN2 STX1A STXBP1 TBC1D1 TRIM37 TRIM41 ZBTB7B ZBTB9 ZRANB1
Entrez ID		26031	94121
HPRD ID		09474	06735
Ensembl ID		ENSG00000070882	ENSG00000102362
Uniprot IDs		Q9H4L5	A0A024RCF8 A8K973 B2R7R4 Q71SF7 Q96C24
PDB IDs		7CYZ	2CSZ 3FDW 5X6T
Enriched GO Terms of Interacting Partners?
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