GORASP2 and FIG4

Data Source:
BioGRID (two hybrid)

		GORASP2	FIG4
Description		golgi reassembly stacking protein 2	FIG4 phosphoinositide 5-phosphatase
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Membrane	Golgi Membrane Lipid Droplet Endosome Membrane Early Endosome Membrane Late Endosome Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	Protein Binding Phosphatidylinositol-3,5-bisphosphate 5-phosphatase Activity
	Biological Process	Organelle Organization Golgi Organization Spermatogenesis Cell Differentiation Response To Endoplasmic Reticulum Stress Establishment Of Protein Localization To Plasma Membrane Organelle Assembly	Phosphatidylinositol Biosynthetic Process Phosphatidylinositol-3-phosphate Biosynthetic Process Phosphatidylinositol Dephosphorylation
Pathways		Golgi Cisternae Pericentriolar Stack Reorganization	Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane
Drugs
Diseases			Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Cognitive performance ( 19734545)	Apolipoprotein B levels ( 32203549) Chronotype ( 30696823) Depression in smokers ( 30219690) Height ( 28552196) Iron status biomarkers (iron levels) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Red cell distribution width ( 32888494)
Interacting Genes		143 interacting genes: AAMDC ACY3 ALKBH4 APIP APP ARHGEF15 ARL6IP1 ASMTL ATP6V1G1 ATXN1L BEND5 BLZF1 BTBD3 C1orf94 C21orf91 CARHSP1 CBLB CBY1 CCDC153 CCDC90B CDA CDC23 CDK18 CDKN2D CEP76 CGGBP1 CHMP1A CNTNAP2 CRYAA CRYAA2 CRYAB DCTD DMC1 DNAJB13 DPYSL2 DUSP21 DUSP4 DYRK3 ECHDC1 EIF2B1 EMILIN3 ENOX1 ENOX2 ETHE1 FIG4 GABPB2 GNG7 GNGT1 GOLGA2 GOLGA6L2 GSTZ1 GTF2IRD1 HOXC5 HSBP1 HSPB11 JADE2 KCTD13 KCTD5 KCTD7 KCTD9 KIFC3 KRTAP5-11 LONRF1 LTBP3 MAP1LC3B MAPK1 MAPK14 MAPK8 MATN4 MID2 MIEN1 MIF MORN2 MPLKIP MSC MYOM3 NCOA5 NHSL2 NME1 NMNAT1 NQO2 NUDT5 NUP62 ODC1 PCBD1 PDE9A PNMA5 PRDX3 PRKAB2 PRPS1 PRRC2A PSMA3 PSMD6 RAB1A RAB27B RAB2A RAB39A RAD54B RBM46 REEP6 RGL2 RGS3 RPIA RPS6KA1 SCAND1 SELENBP1 SEPTIN1 SEPTIN14 SHMT1 STOX1 TAGLN TCF4 TEKT3 TGFA TLE5 TMED10 TMED2 TMED3 TP53RK TPH1 TRAF1 TRAF2 TRAF4 TRAF5 TRAPPC6A TRIM38 TRPT1 TSC22D1 TSC22D4 TSEN15 TSN TTC19 TXLNA UBE2Z UBL3 VPS37B VPS52 XPNPEP1 ZBED1 ZBTB14 ZMAT1 ZMYND19 ZNF148	3 interacting genes: APP GORASP2 VAC14
Entrez ID		26003	9896
HPRD ID		08303	11073
Ensembl ID		ENSG00000115806	ENSG00000112367
Uniprot IDs		Q9H8Y8	A0A6Q8PGB4 Q92562
PDB IDs		3RLE 4EDJ
Enriched GO Terms of Interacting Partners?
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