NECAP1 and DNAJC5

Data Source:
BioGRID (fluorescent resonance energy transfer)

		NECAP1	DNAJC5
Description		NECAP endocytosis associated 1	DnaJ heat shock protein family (Hsp40) member C5
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GO Annotations	Cellular Component	Cytosol Clathrin-coated Pit Clathrin Vesicle Coat	Mitochondrion Lysosomal Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane Anchored Component Of Membrane Neuromuscular Junction Azurophil Granule Membrane Specific Granule Membrane Melanosome Chromaffin Granule Membrane Intracellular Membrane-bounded Organelle Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Anchored Component Of Synaptic Vesicle Membrane
	Molecular Function	Protein Binding	Protein Binding ATP-dependent Protein Binding
	Biological Process	Endocytosis Protein Transport Vesicle-mediated Transport Membrane Organization	Exocytosis Neurotransmitter Secretion Synaptic Vesicle Exocytosis Neutrophil Degranulation Negative Regulation Of Neuron Apoptotic Process Regulated Exocytosis Chaperone-mediated Protein Folding Regulation Of Synaptic Vesicle Cycle
Pathways		Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Neutrophil degranulation GABA synthesis, release, reuptake and degradation
Drugs
Diseases
GWAS			Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732)
Interacting Genes		9 interacting genes: AMPH AP1B1 APP DAB2 DAPK1 DNAJC5 HIP1 REL SNAP91	56 interacting genes: AGFG1 AP2B1 ARHGEF15 BTC CADM1 CADPS CASK CD2 CFTR CGB5 CLCN3 EFNB1 ERC1 FAS FCHO1 GRM8 HBA2 HGS KHDC4 LIN7A LIN7C NECAP1 NRXN3 NUMB PPFIA1 PPFIA4 PRKACA PRKCG PRRC2B PSMD12 RABGEF1 RBSN SCAMP1 SCAMP3 SCAMP5 SH3GL3 SLC17A8 SLC18A2 SLC30A3 SLC32A1 SNAP29 SNAP91 SNCA STX12 STX3 STX4 STX6 STX7 SV2A SYT12 SYT5 SYT9 VAMP1 VAMP3 VAMP4 VAMP7
Entrez ID		25977	80331
HPRD ID		14819	08539
Ensembl ID		ENSG00000089818	ENSG00000101152
Uniprot IDs		Q8NC96	Q6AHX3 Q9H3Z4
PDB IDs		6RH5 6RH6	2N04 2N05
Enriched GO Terms of Interacting Partners?
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