SHPRH and RAD18

Data Source:
BioGRID (pull down)

		SHPRH	RAD18
Description		SNF2 histone linker PHD RING helicase	RAD18 E3 ubiquitin protein ligase
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GO Annotations	Cellular Component	Nucleosome Nucleoplasm	Nucleus Nucleoplasm Replication Fork Cytoplasm Centrosome Nuclear Body Site Of Double-strand Break Nuclear Inclusion Body Rad6-Rad18 Complex
	Molecular Function	DNA Binding Helicase Activity Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Y-form DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Protein Polyubiquitination DNA Repair Nucleosome Assembly Cellular Response To DNA Damage Stimulus Protein Ubiquitination	DNA Repair Postreplication Repair Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Response To UV Protein Ubiquitination DNA Damage Response, Detection Of DNA Damage Protein Autoubiquitination Positive Regulation Of Chromosome Segregation Negative Regulation Of Cell Death
Pathways		E3 ubiquitin ligases ubiquitinate target proteins	Recognition of DNA damage by PCNA-containing replication complex E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS			Chronotype ( 30696823) Clopidogrel active metabolite levels ( 28207573) Metabolite levels ( 23823483) Morning person ( 30696823) Sleep duration ( 30531941) Transverse temporal cortex volume ( 31530798)
Interacting Genes		10 interacting genes: BORCS6 EDARADD FBXW7 FDFT1 LPP RAD18 UBE2D1 UBE2N UBE2V2 YWHAG	30 interacting genes: ARRDC3 DAZAP2 DZIP3 GOLGA2 MAGEA4 MAP3K1 MAPK8 MLKL NBN ORC2 PCGF6 PCNA PDCD5 POLK RAD51 RFC2 SHPRH SIVA1 TAX1BP1 TP53BP1 TRIM23 TRIM8 TSG101 UBC UBE2A UBE2B UBE2D2 UBE2I USP2 USP7
Entrez ID		257218	56852
HPRD ID		10476	09242
Ensembl ID		ENSG00000146414	ENSG00000070950
Uniprot IDs		B3KX98 Q149N8	Q9NS91
PDB IDs		2M85 4QN1	2MRE 2MRF 2Y43 2YBF 5VF0
Enriched GO Terms of Interacting Partners?
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