PAN3 and GSX1

Data Source:
HPRD (in vivo)

		PAN3	GSX1
Description		poly(A) specific ribonuclease subunit PAN3	GS homeobox 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	P-body Cytosol PAN Complex	Chromatin Nucleus
	Molecular Function	RNA Binding Poly(A)-specific Ribonuclease Activity Protein Kinase Activity Protein Binding ATP Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Processing Protein Phosphorylation RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Spinal Cord Association Neuron Differentiation Hypothalamus Development Adenohypophysis Development Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Commitment
Pathways		Deadenylation of mRNA
Drugs
Diseases
GWAS		Bipolar disorder ( 20351715) Body mass index ( 26426971) Granulocyte percentage of myeloid white cells ( 27863252) Hepcidin/transferrin saturation ratio ( 27846281) Mean corpuscular volume ( 32888494) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Pancreatic cancer ( 25086665)	Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) ( 23648065) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Body mass index ( 26426971) Pancreatic cancer ( 25086665) Plasma parathyroid hormone levels ( 30134803)
Interacting Genes		4 interacting genes: PABPC1 PAN2 SVIL TNRC6B	1 interacting genes: KRTAP19-7
Entrez ID		255967	219409
HPRD ID		17818	11016
Ensembl ID		ENSG00000152520	ENSG00000169840
Uniprot IDs		Q58A45	Q9H4S2
PDB IDs
Enriched GO Terms of Interacting Partners?
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