LCE5A and PLAC8

Data Source:
BioGRID (two hybrid)

		LCE5A	PLAC8
Description		late cornified envelope 5A	placenta associated 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Extracellular Region Azurophil Granule Lumen
	Molecular Function	Protein Binding Identical Protein Binding	Chromatin Binding
	Biological Process	Keratinization	Positive Regulation Of Cell Population Proliferation Response To Cold Negative Regulation Of Multicellular Organism Growth Defense Response To Bacterium Negative Regulation Of Apoptotic Process Neutrophil Degranulation Positive Regulation Of Transcription By RNA Polymerase II Brown Fat Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis
Pathways		Formation of the cornified envelope	Neutrophil degranulation
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic march ( 26542096) Hair morphology ( 19896111) Inflammatory skin disease ( 25574825)	QRS interval (sulfonylurea treatment interaction) ( 27958378)
Interacting Genes		66 interacting genes: ADAM12 ALPP CHIC2 CHRD CREB5 CYP21A2 CYSRT1 FBLN1 HOXA1 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP12-4 KRTAP21-2 KRTAP3-1 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 LCE1A LCE1B LCE1C LCE1E LCE1F LCE2B LCE2C LCE4A NBPF19 NECTIN2 NOTCH2NLA NTAQ1 NUTF2 PLAC8 PLSCR2 PLSCR3 PLSCR4 POU4F2 RGS17 RGS20 RNF4 SLC39A7 SMCP SPRED2 SPRY1 TRIM42 UBE2I VWC2L ZNF655	24 interacting genes: BAG4 C19orf54 COPS5 CYSRT1 FCHO1 KRTAP12-2 KRTAP19-1 KRTAP19-6 LCE1A LCE1C LCE2B LCE5A MEOX2 PLAGL2 PPP3CA RBPMS RHOXF2 TEX37 TRAF1 TRIP13 UBAP2 USP54 VAMP5 WWOX
Entrez ID		254910	51316
HPRD ID		17265	06335
Ensembl ID		ENSG00000186207	ENSG00000145287
Uniprot IDs		Q5TCM9	Q9NZF1 X2BQ60
PDB IDs
Enriched GO Terms of Interacting Partners?
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