MSRB3 and PRDM4

Data Source:
BioGRID (two hybrid)

		MSRB3	PRDM4
Description		methionine sulfoxide reductase B3	PR/SET domain 4
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol	Nucleus Cytoplasm Histone Methyltransferase Complex
	Molecular Function	Protein Binding Zinc Ion Binding Peptide-methionine (R)-S-oxide Reductase Activity L-methionine-(R)-S-oxide Reductase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Methyltransferase Activity Metal Ion Binding Histone Methyltransferase Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Response To Oxidative Stress Protein Repair	Transcription By RNA Polymerase II Regulation Of Gene Expression Histone H4-R3 Methylation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Protein repair	p75NTR negatively regulates cell cycle via SC1
Drugs
Diseases
GWAS		Antisaccade task score ( 31596458) Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Dentate gyrus granule cell layer volume ( 30279459) Dentate gyrus molecular layer volume ( 30279459) Differentiated thyroid cancer ( 28703219) FEV1 ( 30804560) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Height ( 31562340) Hippocampal fissure volume ( 30279459) Hippocampal subfield CA1 volume ( 30279459) Hippocampal subfield CA1 volume (corrected for total hippocampal volume) ( 30279459) Hippocampal subfield CA3 volume ( 30279459) Hippocampal subfield CA4 volume ( 30279459) Hippocampal volume ( 28098162 22504421) Lung function (FEV1) ( 28166213) Lung function (FVC) ( 30804560) Papillary thyroid cancer ( 28703219) Peak expiratory flow ( 30804560) Post bronchodilator FEV1/FVC ratio ( 26634245) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Subcortical brain region volumes ( 25607358) Subiculum volume ( 30279459) Temperament ( 22832960) Temporal lobe volume ( 31396565) Total hippocampal volume ( 30279459) Type 2 diabetes nephropathy ( 21150874)	Acne (severe) ( 24927181) Sleep duration ( 30846698)
Interacting Genes		32 interacting genes: ASB13 BANP CTBP2 EEF1AKMT3 EFEMP1 EIF6 FAM168B FHL3 GOLGA2 KRT31 KRT34 KRT40 LCN2 LNX2 MAPK8IP2 MED12L METTL15 METTL21A MGLL PICK1 PLEKHG4 POU6F2 PRDM4 REL TCF4 TRIM23 TRIM55 TRIM63 TRIP6 UFSP1 WDR61 ZMYND12	7 interacting genes: CTNNBL1 EIF4E EMX1 MSRB3 NCS1 SERTAD1 SMAD3
Entrez ID		253827	11108
HPRD ID		14785	10425
Ensembl ID		ENSG00000174099	ENSG00000110851
Uniprot IDs		Q8IXL7	A0A024RBM7 B3KPI0 Q9UKN5
PDB IDs		6QA0	2L9Z 3DB5
Enriched GO Terms of Interacting Partners?
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