PRDM4 and NCS1

Data Source:
BioGRID (two hybrid)

		PRDM4	NCS1
Description		PR/SET domain 4	neuronal calcium sensor 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Histone Methyltransferase Complex	Cytoplasm Golgi Apparatus Plasma Membrane Postsynaptic Density Dendrite Dense Core Granule Intracellular Membrane-bounded Organelle Calyx Of Held Perinuclear Region Of Cytoplasm Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Methyltransferase Activity Metal Ion Binding Histone Methyltransferase Binding Sequence-specific Double-stranded DNA Binding	Magnesium Ion Binding Voltage-gated Calcium Channel Activity Calcium Ion Binding Protein Binding Protein Kinase Binding Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels
	Biological Process	Transcription By RNA Polymerase II Regulation Of Gene Expression Histone H4-R3 Methylation Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of Neuron Projection Development Positive Regulation Of Exocytosis Phosphatidylinositol-mediated Signaling Calcium Ion Transmembrane Transport Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Synaptic Vesicle Exocytosis
Pathways		p75NTR negatively regulates cell cycle via SC1
Drugs			Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Acne (severe) ( 24927181) Sleep duration ( 30846698)	Alzheimer's disease (cognitive decline) ( 23535033) Tuberculosis ( 30713548)
Interacting Genes		7 interacting genes: CTNNBL1 EIF4E EMX1 MSRB3 NCS1 SERTAD1 SMAD3	27 interacting genes: C1QTNF2 CDSN CEP89 CREM CTAG1A CTAG1B DRD2 DRD3 DRD5 DTX2 FZD7 GRK2 IL1RAPL1 KCND2 LY6G6D MEOX2 MIEF2 NBL1 OXER1 PI4KB PRDM4 RNASEH1 SFTPA2 SIGLEC9 SPP1 SPRED2 ZC3H10
Entrez ID		11108	23413
HPRD ID		10425	04500
Ensembl ID		ENSG00000110851	ENSG00000107130
Uniprot IDs		A0A024RBM7 B3KPI0 Q9UKN5	A0A024R8B2 P62166
PDB IDs		2L9Z 3DB5	1G8I 2LCP 4GUK 5O9S 6QI4
Enriched GO Terms of Interacting Partners?
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