FUS and ESRRA

Data Source:
BioGRID (two hybrid)

		FUS	ESRRA
Description		FUS RNA binding protein	estrogen related receptor alpha
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GO Annotations	Cellular Component	Nucleus Nucleoplasm	Chromatin Fibrillar Center Nucleus Nucleoplasm Cytoplasm Microtubule Cytoskeleton Intercellular Bridge
	Molecular Function	DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding Protein Binding Identical Protein Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II RNA Splicing Regulation Of RNA Splicing Positive Regulation Of Transcription, DNA-templated MRNA Stabilization Protein Homooligomerization Positive Regulation Of Double-strand Break Repair Via Homologous Recombination	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Mitochondrion Organization Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II
Pathways		mRNA Splicing - Major Pathway	PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis Nuclear Receptor transcription pathway Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity
Drugs			Troglitazone Diethylstilbestrol Genistein Afimoxifene beta-Naphthoflavone 1-CYCLOHEXYL-N-{[1-(4-METHYLPHENYL)-1H-INDOL-3-YL]METHYL}METHANAMINE Flavone
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Myxoid liposarcoma
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) HDL cholesterol levels ( 32203549)	Crohn's disease ( 28067908 21102463) Vitiligo ( 27723757)
Interacting Genes		117 interacting genes: ADAMTS9-AS2 AKT1 ARID1A ATXN1L CTNNB1 ESRRA EWSR1 GRIN1 GRIN2D IL7R ILF3 KHDRBS3 MAX MDH1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NKD2 POLR2A PRMT1 PSMB7 PTBP1 RBMX RELA RXRA SAFB2 SF1 SFPQ SMARCB1 SMARCC1 SMARCC2 SMARCD1 SPI1 SRRM1 SRSF10 SRSF2 SRSF4 SRSF9 SS18 SUV39H1 TARDBP TDRD3 THRA TNIP1 UBQLN2 WBP4 YBX1 ZMYM2	36 interacting genes: ADH5 ATXN1 DUT ESR1 ESRRG EXOSC6 FAM9A FUS GTF2B HDAC8 HIF1A KAT2B LYST MACF1 MAP2K5 NCOA1 NCOA3 NR0B1 NR0B2 NRIP1 NSD1 NXF1 PIAS4 PNRC2 PPARG PPARGC1A PRKCD PROX1 PSMC5 REL RNF4 RXRA SIRT1 SMARCD3 SP1 TNNI2
Entrez ID		2521	2101
HPRD ID		00660	07210
Ensembl ID		ENSG00000089280	ENSG00000173153
Uniprot IDs		P35637 Q13344 Q6IBQ5	P11474 Q569H8
PDB IDs		2LA6 2LCW 4FDD 4FQ3 5W3N 5XRR 5XSG 5YVG 5YVH 5YVI 6BWZ 6BXV 6BZP 6G99 6GBM 6KJ1 6KJ2 6KJ3 6KJ4 6SNJ 6XFM	1XB7 2PJL 3D24 3K6P
Enriched GO Terms of Interacting Partners?
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