FUS and THRA

Data Source:
HPRD (in vitro)

		FUS	THRA
Description		FUS RNA binding protein	thyroid hormone receptor alpha
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GO Annotations	Cellular Component	Nucleus Nucleoplasm	Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding Protein Binding Identical Protein Binding Metal Ion Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding TBP-class Protein Binding Protein Domain Specific Binding Chromatin DNA Binding Protein-containing Complex Binding Thyroid Hormone Binding
	Biological Process	MRNA Splicing, Via Spliceosome Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II RNA Splicing Regulation Of RNA Splicing Positive Regulation Of Transcription, DNA-templated MRNA Stabilization Protein Homooligomerization Positive Regulation Of Double-strand Break Repair Via Homologous Recombination	Negative Regulation Of Transcription By RNA Polymerase II Cartilage Condensation Ossification Thyroid Hormone Mediated Signaling Pathway Regulation Of Thyroid Hormone Mediated Signaling Pathway Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Learning Or Memory Regulation Of Heart Contraction Female Courtship Behavior Response To Cold Hormone-mediated Signaling Pathway Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Cell Differentiation Erythrocyte Differentiation Thyroid Gland Development Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Female Receptivity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Lipid Catabolic Process Type I Pneumocyte Differentiation Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of DNA-templated Transcription, Initiation
Pathways		mRNA Splicing - Major Pathway	Nuclear Receptor transcription pathway
Drugs			Liothyronine Levothyroxine Dextrothyroxine Amiodarone Liotrix KB-141 Dronedarone Eprotirome NRP409 Thyroid, porcine
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Myxoid liposarcoma
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) HDL cholesterol levels ( 32203549)	Asthma ( 31619474) Bipolar disorder ( 31043756) Chronic obstructive pulmonary disease ( 30804561) Pancreatic ductal adenocarcinoma ( 30541042) White blood cell count ( 21738480)
Interacting Genes		117 interacting genes: ADAMTS9-AS2 AKT1 ARID1A ATXN1L CTNNB1 ESRRA EWSR1 GRIN1 GRIN2D IL7R ILF3 KHDRBS3 MAX MDH1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NKD2 POLR2A PRMT1 PSMB7 PTBP1 RBMX RELA RXRA SAFB2 SF1 SFPQ SMARCB1 SMARCC1 SMARCC2 SMARCD1 SPI1 SRRM1 SRSF10 SRSF2 SRSF4 SRSF9 SS18 SUV39H1 TARDBP TDRD3 THRA TNIP1 UBQLN2 WBP4 YBX1 ZMYM2	69 interacting genes: - AKAP13 AMOT AMOTL2 ARID5A BTG1 BUB3 C1D CCND1 CD160 CDK7 CEP76 CLIC1 COPS2 CREB1 CREBBP CUL1 DAP3 ESR1 FOXJ1 FUS GRIP1 GTF2B HDAC2 HDAC3 ITGB3BP L3MBTL3 MED1 MED21 MED25 MEF2A MEOX2 MTNR1B NCOA1 NCOA2 NCOA6 NCOR1 NCOR2 NR0B2 NR2F1 NRIP1 NSD1 OASL PML POU2F1 PRKAR1B PRKDC PTGES3 RANBP9 RGN RXRA RXRB RXRG SELENOP SLC16A2 SRC SUV39H1 SYAP1 TACC1 TBL1X TDG TRIM24 TRIM63 TRIP11 TXNRD1 UBE2I YWHAH YWHAQ ZBTB3
Entrez ID		2521	7067
HPRD ID		00660	07185
Ensembl ID		ENSG00000089280	ENSG00000126351
Uniprot IDs		P35637 Q13344 Q6IBQ5	P10827 Q6FH41
PDB IDs		2LA6 2LCW 4FDD 4FQ3 5W3N 5XRR 5XSG 5YVG 5YVH 5YVI 6BWZ 6BXV 6BZP 6G99 6GBM 6KJ1 6KJ2 6KJ3 6KJ4 6SNJ 6XFM	1NAV 2H77 2H79 3HZF 3ILZ 3JZB 4LNW 4LNX
Enriched GO Terms of Interacting Partners?
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