NR5A1 and PNRC2

Data Source:
HPRD (in vivo, two hybrid)

		NR5A1	PNRC2
Description		nuclear receptor subfamily 5 group A member 1	proline rich nuclear receptor coactivator 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol RNA Polymerase II Transcription Regulator Complex	P-body Nucleus Nucleoplasm Golgi Apparatus Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Nuclear Receptor Activity Protein Binding Phospholipid Binding Zinc Ion Binding Enzyme Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Luteinization Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Sex Determination Primary Sex Determination Male Gonad Development Female Gonad Development Hormone-mediated Signaling Pathway Tissue Development Multicellular Organism Aging Positive Regulation Of Gene Expression Cell Differentiation Male Sex Determination Adrenal Gland Development Intracellular Receptor Signaling Pathway Hormone Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Steroid Biosynthetic Process Maintenance Of Protein Location In Nucleus Response To Gonadotropin-releasing Hormone Calcineurin-mediated Signaling Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Deadenylation-independent Decapping Of Nuclear-transcribed MRNA
Pathways		Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Transcriptional regulation of pluripotent stem cells Transcriptional regulation of testis differentiation	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		(2R)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(9E)-HEXADEC-9-ENOYLOXY]PROPYL (9E)-OCTADEC-9-ENOATE Phosphatidyl ethanol
Diseases		Premature ovarian failure 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Chronotype ( 30696823)	Obesity-related traits ( 23251661)
Interacting Genes		35 interacting genes: AR C2CD6 CKS1B CREBBP CTNNB1 CXXC1 EDF1 GATA4 GTF2B JUN MAPK1 NCK2 NCOA1 NFKB2 NFYA NR0B1 NRIP1 NTAQ1 PIAS1 PITX1 PNRC2 PROX1 RAD54L2 RFC5 SMARCD3 SOX2 SOX8 SOX9 SP1 TBX19 TEKT4 TRAPPC2 TRERF1 UBE2I ZNF653	23 interacting genes: APP AR BANP DCP1A ESR1 ESR2 ESRRA ESRRG FBXO7 GALK1 GLOD4 HNF4A HNF4G NR5A1 NR5A2 RARA RARG RORA RORB SPAG9 XRCC6 ZBTB16 ZBTB48
Entrez ID		2516	55629
HPRD ID		01702	17871
Ensembl ID		ENSG00000136931	ENSG00000189266
Uniprot IDs		F1D8R8 Q13285	Q9NPJ4
PDB IDs		1YOW 1ZDT 4QJR 4QK4	4B6H 5KQ1 5KQ4
Enriched GO Terms of Interacting Partners?
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