MTOR and GSK3B

Data Source:
BioGRID (two hybrid)

		MTOR	GSK3B
Description		mechanistic target of rapamycin kinase	glycogen synthase kinase 3 beta
Image
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Lysosome Lysosomal Membrane Endoplasmic Reticulum Membrane Cytosol Endomembrane System Membrane PML Body Dendrite TORC1 Complex TORC2 Complex Neuronal Cell Body Phagocytic Vesicle Glutamatergic Synapse Postsynaptic Cytosol	Nucleus Nucleoplasm Cytoplasm Mitochondrion Centrosome Cytosol Plasma Membrane Axon Dendrite Beta-catenin Destruction Complex Postsynapse Glutamatergic Synapse Wnt Signalosome
	Molecular Function	RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding TFIIIC-class Transcription Factor Complex Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Protein Kinase Binding Protein Domain Specific Binding Identical Protein Binding Ribosome Binding Translation Regulator Activity Phosphoprotein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	RNA Polymerase II Transcription Factor Binding Protease Binding P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Beta-catenin Binding Kinase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding Dynactin Binding Tau Protein Binding Tau-protein Kinase Activity NF-kappaB Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Regulation Of Cell Growth Negative Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation T-helper 1 Cell Lineage Commitment Heart Morphogenesis Heart Valve Morphogenesis Regulation Of Glycogen Biosynthetic Process Energy Reserve Metabolic Process 'de Novo' Pyrimidine Nucleobase Biosynthetic Process Protein Phosphorylation Lysosome Organization Cell Cycle Arrest Germ Cell Development Brain Development Cell Aging Response To Nutrient Long-term Memory Regulation Of Cell Size Visual Learning Cellular Response To Starvation Post-embryonic Development Negative Regulation Of Autophagy Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Myotube Differentiation Positive Regulation Of Neuron Projection Development Positive Regulation Of Neuron Maturation Negative Regulation Of Muscle Atrophy Response To Activity Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Spinal Cord Development Protein Catabolic Process Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Ubiquitination Ruffle Organization Regulation Of Myelination Response To Nutrient Levels Cellular Response To Nutrient Levels TOR Signaling Regulation Of Fatty Acid Beta-oxidation Regulation Of Response To Food Activation Of Protein Kinase B Activity Positive Regulation Of Phosphoprotein Phosphatase Activity Response To Insulin Regulation Of Actin Cytoskeleton Organization Cellular Response To Amino Acid Starvation Social Behavior Multicellular Organism Growth TORC1 Signaling Wound Healing Response To Cocaine Regulation Of Circadian Rhythm Regulation Of GTPase Activity Response To Amino Acid Anoikis Response To Morphine Regulation Of Carbohydrate Utilization Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Osteoclast Differentiation Positive Regulation Of Translation Negative Regulation Of Cell Size Positive Regulation Of Transcription By RNA Polymerase III Protein Autophosphorylation Positive Regulation Of Lipid Biosynthetic Process MRNA Stabilization Rhythmic Process Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Voluntary Musculoskeletal Movement Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Keratinocyte Migration Nucleus Localization Positive Regulation Of Protein Kinase B Signaling Cardiac Muscle Cell Development Cardiac Muscle Contraction Maternal Process Involved In Female Pregnancy Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Dendritic Spine Development Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Amino Acid Stimulus Cellular Response To Leucine Cellular Response To Hypoxia Regulation Of Brown Fat Cell Differentiation Regulation Of Membrane Permeability Regulation Of Translation At Synapse, Modulating Synaptic Transmission Regulation Of Cellular Response To Heat Positive Regulation Of Neuron Death Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Eating Behavior Positive Regulation Of Cholangiocyte Proliferation Positive Regulation Of Sensory Perception Of Pain Regulation Of Locomotor Rhythm Negative Regulation Of Cholangiocyte Apoptotic Process Positive Regulation Of Granulosa Cell Proliferation Positive Regulation Of Skeletal Muscle Hypertrophy Negative Regulation Of Iodide Transmembrane Transport Positive Regulation Of Cytoplasmic Translational Initiation Cellular Response To Leucine Starvation	Epithelial To Mesenchymal Transition Positive Regulation Of Cell-matrix Adhesion Glycogen Metabolic Process Protein Phosphorylation ER Overload Response Signal Transduction Dopamine Receptor Signaling Pathway Circadian Rhythm Insulin Receptor Signaling Pathway Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Positive Regulation Of Mitochondrion Organization Regulation Of Neuron Projection Development Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Hippocampus Development Establishment Of Cell Polarity Maintenance Of Cell Polarity Regulation Of Axon Extension Neuron Projection Development Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein Binding Positive Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Microtubule-based Process Intracellular Signal Transduction Cellular Response To Interleukin-3 Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Protein Catabolic Process Protein Autophosphorylation Positive Regulation Of Protein Export From Nucleus Regulation Of Dendrite Morphogenesis Regulation Of Axonogenesis Excitatory Postsynaptic Potential Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Calcineurin-NFAT Signaling Cascade Superior Temporal Gyrus Development Negative Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Neuron Projection Organization Regulation Of Microtubule Anchoring At Centrosome Regulation Of Cellular Response To Heat Negative Regulation Of Protein Localization To Nucleus Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Neuron Death Positive Regulation Of Neuron Death Negative Regulation Of Protein Acetylation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Dopaminergic Neuron Differentiation Cellular Response To Amyloid-beta Positive Regulation Of Protein Localization To Centrosome Beta-catenin Destruction Complex Assembly Beta-catenin Destruction Complex Disassembly Negative Regulation Of Type B Pancreatic Cell Development Regulation Of Synaptic Vesicle Exocytosis Negative Regulation Of Glycogen (starch) Synthase Activity
Pathways		PIP3 activates AKT signaling Macroautophagy MTOR signalling mTORC1-mediated signalling HSF1-dependent transactivation Energy dependent regulation of mTOR by LKB1-AMPK CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of PTEN gene transcription Amino acids regulate mTORC1	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade AKT phosphorylates targets in the cytosol Regulation of HSF1-mediated heat shock response CRMPs in Sema3A signaling Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane B-WICH complex positively regulates rRNA expression Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Constitutive Signaling by AKT1 E17K in Cancer Ubiquitin-dependent degradation of Cyclin D Regulation of RUNX2 expression and activity Replication of the SARS-CoV-1 genome Maturation of nucleoprotein Maturation of nucleoprotein Maturation of nucleoprotein Replication of the SARS-CoV-2 genome
Drugs		Pimecrolimus Sirolimus Everolimus Rimiducid SF1126 XL765 Ridaforolimus Temsirolimus Fostamatinib	Lithium cation 3-[3-(2,3-Dihydroxy-Propylamino)-Phenyl]-4-(5-Fluoro-1-Methyl-1h-Indol-3-Yl)-Pyrrole-2,5-Dione SB-409513 AR-AO-14418 Staurosporine Indirubin-3'-monoxime 6-bromoindirubin-3'-oxime Alsterpaullone Phosphoaminophosphonic Acid-Adenylate Ester 2-(1,3-benzodioxol-5-yl)-5-[(3-fluoro-4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazole 5-[1-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazole-2(3H)-thione (7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE Fostamatinib Tideglusib Lithium citrate Lithium succinate Lithium carbonate
Diseases
GWAS		Beard thickness ( 26926045) Body mass index ( 25673413) Corneal curvature ( 24963161) Heel bone mineral density ( 28869591) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)	HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Low density lipoprotein cholesterol levels ( 32154731) Neutrophil count ( 32888494) Platelet distribution width ( 32888494)
Interacting Genes		52 interacting genes: AKT1 AKT1S1 AMBRA1 BCL2L1 C7orf25 CDC37 CFP CLIP1 DCP2 EIF3F EIF4EBP1 EIF4EBP2 EP300 ESR1 FBXO8 FKBP1A FKBP8 GPHN GSK3B HRAS IRS1 MAF1 MLST8 NRAS PA2G4 PDPK1 PLD2 PPP2R2A PREX1 PRKAA1 PRKCA PRR5L RHEB RHEBL1 RICTOR RPS6KA1 RPS6KB1 RPS6KB2 RPTOR RRAGB SEPTIN2 SKP2 STAT3 SUMO1 TELO2 TERT TRAF6 UBQLN1 UVRAG WIPI2 YWHAQ ZNRF2	225 interacting genes: ACLY ACSBG1 ACTL6B ADAP1 ADIRF AKAP11 AKT1 AKT2 AKT3 APC APP AR ARRB1 ASRGL1 ATP5IF1 ATXN3 AURKA AXIN1 AXIN2 BAG6 BCL2A1 BCL2L1 BCL3 BEX1 BHLHE41 BICD1 BICD2 BRIX1 BTRC BZW2 CABYR CAMSAP3 CCND1 CCNE1 CDH1 CDK5 CDX2 CEBPA CEBPD CEBPZ CENPB CHD3 CIITA CLEC3B CREB1 CREB3L3 CREM CSAD CSNK2B CST6 CTNNB1 CTNND1 DBI DCTN1 DCTN2 DCTN3 DDIT4 DEAF1 DEFA1 DELEC1 DHX34 DISC1 DNAJC13 DNM1L DNMT1 DNMT3L DPYSL2 DUSP9 DYNC1I1 E2F1 EEF1G EFTUD2 EIF2B5 EIF4EBP1 ENTPD6 ERG28 EYA1 FAM193B FAM83D FBN3 FBXO7 FBXW11 FEN1 FIBP FKBP14 FOXO1 FRAT1 FRAT2 FZD5 GBP2 GFI1 GIPC1 GJB5 GNB2 GPR39 GYS1 HDAC4 HNRNPD HSP90AA1 HSPA4 IGHM IGSF21 IKBKG ILK IQCG IRF1 JUN KDM1A KHSRP KIAA1191 KIF5B KLF2 KLF5 LMO4 LPCAT1 LRP6 LUC7L2 MAP1B MAP3K1 MAP3K4 MAP4 MAPK1 MAPT MARK2 MASP1 MCL1 MDM2 MED24 MICAL1 MID1IP1 MITF MPP1 MTF2 MTOR MUC1 MYC MYOCD NAT9 NBR1 NCOA3 NDRG1 NFE2L1 NFE2L2 NFE2L3 NFKB1 NIN NOTCH1 NOTCH2 NRBP1 NSFL1C OGA OGT PDE4D PFKFB4 PHLPP1 PIAS1 PIM2 PMAIP1 PPARGC1A PPP1R2 PRKACA PRKCA PRKCB PRKCZ PRKDC PSEN1 PTK2 PTN PTPN1 PXN QARS1 RAI1 RBPJ RCAN1 RELB RICTOR RPL36AL RPLP1 RPS2 RPS6KA1 RSU1 RXRA SAP30BP SGK1 SGK3 SLA SMAD3 SNAI1 SNCA SNCAIP SOX10 SPTBN4 SREBF1 STAT2 SYNE4 TAZ TLE1 TMEM132A TMEM44 TNFAIP3 TONSL TP53 TPPP TRAF6 TSC2 TUBA1A UBE2D1 UBR1 UBR5 UBXN6 UFM1 UPF3A VIM VPS51 WSB1 XIAP XPNPEP1 YBX1 YBX3 YWHAZ ZFPM1 ZHX1 ZNF135 ZNF227 ZNF746
Entrez ID		2475	2932
HPRD ID		03134	05418
Ensembl ID		ENSG00000198793	ENSG00000082701
Uniprot IDs		P42345	P49841 Q6FI27
PDB IDs		1AUE 1FAP 1NSG 2FAP 2GAQ 2NPU 2RSE 3FAP 3JBZ 4DRH 4DRI 4DRJ 4FAP 4JSN 4JSP 4JSV 4JSX 4JT5 4JT6 5FLC 5GPG 5H64 5WBH 5WBU 5WBY 5ZCS 6BCU 6BCX 6M4U 6M4W 6SB0 6SB2	1GNG 1H8F 1I09 1J1B 1J1C 1O6K 1O6L 1O9U 1PYX 1Q3D 1Q3W 1Q41 1Q4L 1Q5K 1R0E 1UV5 2JDO 2JDR 2JLD 2O5K 2OW3 2UW9 2X39 2XH5 3CQU 3CQW 3DU8 3E87 3E88 3E8D 3F7Z 3F88 3GB2 3I4B 3L1S 3M1S 3MV5 3OW4 3PUP 3Q3B 3QKK 3SAY 3SD0 3ZDI 3ZRK 3ZRL 3ZRM 4ACC 4ACD 4ACG 4ACH 4AFJ 4B7T 4DIT 4EKK 4IQ6 4J1R 4J71 4NM0 4NM3 4NM5 4NM7 4PTC 4PTE 4PTG 5F94 5F95 5HLN 5HLP 5K5N 5KPK 5KPL 5KPM 5OY4 5T31 6B8J 6BUU 6GJO 6GN1 6H0U 6HK3 6HK4 6HK7 6NPZ 6TCU 6V6L 6Y9R 6Y9S
Enriched GO Terms of Interacting Partners?
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