MTOR and CDC37

Data Source:
BioGRID (two hybrid)

		MTOR	CDC37
Description		mechanistic target of rapamycin kinase	cell division cycle 37, HSP90 cochaperone
Image
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Lysosome Lysosomal Membrane Endoplasmic Reticulum Membrane Cytosol Endomembrane System Membrane PML Body Dendrite TORC1 Complex TORC2 Complex Neuronal Cell Body Phagocytic Vesicle Glutamatergic Synapse Postsynaptic Cytosol	Cytoplasm Cytosol Extracellular Exosome Chaperone Complex HSP90-CDC37 Chaperone Complex
	Molecular Function	RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding TFIIIC-class Transcription Factor Complex Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Protein Kinase Binding Protein Domain Specific Binding Identical Protein Binding Ribosome Binding Translation Regulator Activity Phosphoprotein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding Protein Kinase Regulator Activity Kinase Binding Protein Kinase Binding Heat Shock Protein Binding Unfolded Protein Binding Chaperone Binding Hsp90 Protein Binding Scaffold Protein Binding
	Biological Process	Regulation Of Cell Growth Negative Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation T-helper 1 Cell Lineage Commitment Heart Morphogenesis Heart Valve Morphogenesis Regulation Of Glycogen Biosynthetic Process Energy Reserve Metabolic Process 'de Novo' Pyrimidine Nucleobase Biosynthetic Process Protein Phosphorylation Lysosome Organization Cell Cycle Arrest Germ Cell Development Brain Development Cell Aging Response To Nutrient Long-term Memory Regulation Of Cell Size Visual Learning Cellular Response To Starvation Post-embryonic Development Negative Regulation Of Autophagy Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Myotube Differentiation Positive Regulation Of Neuron Projection Development Positive Regulation Of Neuron Maturation Negative Regulation Of Muscle Atrophy Response To Activity Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Spinal Cord Development Protein Catabolic Process Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Ubiquitination Ruffle Organization Regulation Of Myelination Response To Nutrient Levels Cellular Response To Nutrient Levels TOR Signaling Regulation Of Fatty Acid Beta-oxidation Regulation Of Response To Food Activation Of Protein Kinase B Activity Positive Regulation Of Phosphoprotein Phosphatase Activity Response To Insulin Regulation Of Actin Cytoskeleton Organization Cellular Response To Amino Acid Starvation Social Behavior Multicellular Organism Growth TORC1 Signaling Wound Healing Response To Cocaine Regulation Of Circadian Rhythm Regulation Of GTPase Activity Response To Amino Acid Anoikis Response To Morphine Regulation Of Carbohydrate Utilization Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Osteoclast Differentiation Positive Regulation Of Translation Negative Regulation Of Cell Size Positive Regulation Of Transcription By RNA Polymerase III Protein Autophosphorylation Positive Regulation Of Lipid Biosynthetic Process MRNA Stabilization Rhythmic Process Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Voluntary Musculoskeletal Movement Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Keratinocyte Migration Nucleus Localization Positive Regulation Of Protein Kinase B Signaling Cardiac Muscle Cell Development Cardiac Muscle Contraction Maternal Process Involved In Female Pregnancy Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Dendritic Spine Development Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Amino Acid Stimulus Cellular Response To Leucine Cellular Response To Hypoxia Regulation Of Brown Fat Cell Differentiation Regulation Of Membrane Permeability Regulation Of Translation At Synapse, Modulating Synaptic Transmission Regulation Of Cellular Response To Heat Positive Regulation Of Neuron Death Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Eating Behavior Positive Regulation Of Cholangiocyte Proliferation Positive Regulation Of Sensory Perception Of Pain Regulation Of Locomotor Rhythm Negative Regulation Of Cholangiocyte Apoptotic Process Positive Regulation Of Granulosa Cell Proliferation Positive Regulation Of Skeletal Muscle Hypertrophy Negative Regulation Of Iodide Transmembrane Transport Positive Regulation Of Cytoplasmic Translational Initiation Cellular Response To Leucine Starvation	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Folding Protein Targeting Posttranscriptional Regulation Of Gene Expression ERBB2 Signaling Pathway Protein Stabilization Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization
Pathways		PIP3 activates AKT signaling Macroautophagy MTOR signalling mTORC1-mediated signalling HSF1-dependent transactivation Energy dependent regulation of mTOR by LKB1-AMPK CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of PTEN gene transcription Amino acids regulate mTORC1	Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Constitutive Signaling by EGFRvIII Regulation of necroptotic cell death Downregulation of ERBB2 signaling RHOBTB2 GTPase cycle Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants
Drugs		Pimecrolimus Sirolimus Everolimus Rimiducid SF1126 XL765 Ridaforolimus Temsirolimus Fostamatinib
Diseases
GWAS		Beard thickness ( 26926045) Body mass index ( 25673413) Corneal curvature ( 24963161) Heel bone mineral density ( 28869591) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 21833088) White blood cell count ( 32888494)
Interacting Genes		52 interacting genes: AKT1 AKT1S1 AMBRA1 BCL2L1 C7orf25 CDC37 CFP CLIP1 DCP2 EIF3F EIF4EBP1 EIF4EBP2 EP300 ESR1 FBXO8 FKBP1A FKBP8 GPHN GSK3B HRAS IRS1 MAF1 MLST8 NRAS PA2G4 PDPK1 PLD2 PPP2R2A PREX1 PRKAA1 PRKCA PRR5L RHEB RHEBL1 RICTOR RPS6KA1 RPS6KB1 RPS6KB2 RPTOR RRAGB SEPTIN2 SKP2 STAT3 SUMO1 TELO2 TERT TRAF6 UBQLN1 UVRAG WIPI2 YWHAQ ZNRF2	178 interacting genes: A2M ACTB ACTG1 AKT1 AMOTL2 APOE APP AR BEND7 BHLHB9 BLZF1 BTBD10 BTBD3 C19orf44 CAMK2A CAMK2B CAMK2G CARD10 CARD9 CAVIN1 CBY2 CC2D1A CCDC138 CCDC152 CCDC91 CCHCR1 CDC37L1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CEP55 CEP70 CGGBP1 CHGA CHUK CKS1B CKS2 CRYM CSNK2A1 CSNK2A2 CT45A1 CTAG1A CTAG1B CUTC CYP2C9 DCTN1 DEAF1 DISC1 ECSIT EIF2AK1 EIF2S1 ELAVL3 ENOX2 EXOSC1 FAM118A FAM9B FATE1 FBXL12 FBXW4 GAS7 GAS8 GCDH GCH1 GFAP GMCL1 GOLGA2 GOLGA6L9 GRAMD2B GRIPAP1 HIVEP1 HOMER3 HSF2BP HSP90AA1 IFIT5 IKBKB IKBKE IKBKG IKZF3 IMMT JRK KATNBL1 KCTD13 KCTD9 KIFC3 KLHL2 KRT75 KRT76 LMNB2 LONP1 LOXL4 LUC7L2 LZTS1 MAD1L1 MAP3K14 MAP3K3 MDFI MID1 MIPOL1 MRPL9 MTOR MZT2B NCOA5 NECAB1 NECAB2 NOS3 NR2C2 NRIP3 NT5C1A OGA PAICS PDE9A PIBF1 PNMA2 POU6F2 PPHLN1 PPP5C PRAM1 PRDX2 PRKAR1B PRMT1 PRMT5 PRPH PRR20A PRR20B PRR20C PRR20D PRR20E PSMC6 PSME1 PTGES3 RABGEF1 RAD23A RAF1 REEP6 RNF32 ROPN1 RPS15A SAFB SEPTIN3 SNX5 SPTBN4 SQSTM1 SRC SRRM4 SSNA1 STAMBPL1 STIP1 STK11 STK32A STX1A SYCE2 SYCP3 TBK1 TCF4 THAP1 THAP7 TNFAIP1 TNIP1 TRAF2 TRAF3 TRAF5 TRIM54 UBE2I USHBP1 WAC ZBED1 ZBTB26 ZBTB8A ZNF205 ZNF235 ZNF266 ZNF276 ZNF655 ZNF667 ZNF837
Entrez ID		2475	11140
HPRD ID		03134	05456
Ensembl ID		ENSG00000198793	ENSG00000105401
Uniprot IDs		P42345	A0A024R7B7 Q16543
PDB IDs		1AUE 1FAP 1NSG 2FAP 2GAQ 2NPU 2RSE 3FAP 3JBZ 4DRH 4DRI 4DRJ 4FAP 4JSN 4JSP 4JSV 4JSX 4JT5 4JT6 5FLC 5GPG 5H64 5WBH 5WBU 5WBY 5ZCS 6BCU 6BCX 6M4U 6M4W 6SB0 6SB2	1US7 2K5B 2N5X 2NCA 2W0G 5FWK 5FWL 5FWM 5FWP 5HPE
Enriched GO Terms of Interacting Partners?
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