ALOX12B and KRT5

Data Source:
HPRD (in vivo, two hybrid)

		ALOX12B	KRT5
Description		arachidonate 12-lipoxygenase, 12R type	keratin 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Cytosol Intermediate Filament Membrane Keratin Filament Extracellular Exosome
	Molecular Function	Arachidonate 12(S)-lipoxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Lyase Activity Isomerase Activity Arachidonate 8(R)-lipoxygenase Activity Linoleate 9S-lipoxygenase Activity	Structural Constituent Of Cytoskeleton Protein Binding Scaffold Protein Binding
	Biological Process	Protein Lipidation Sphingolipid Metabolic Process Positive Regulation Of Gene Expression Arachidonic Acid Metabolic Process Lipoxygenase Pathway Lipid Oxidation Positive Regulation Of MAPK Cascade Linoleic Acid Metabolic Process Ceramide Biosynthetic Process Hepoxilin Biosynthetic Process Establishment Of Skin Barrier Positive Regulation Of Mucus Secretion	Cytoskeleton Organization Epidermis Development Keratinization Hemidesmosome Assembly Cornification
Pathways		Synthesis of 12-eicosatetraenoic acid derivatives	Type I hemidesmosome assembly Keratinization Formation of the cornified envelope
Drugs			Zinc Zinc acetate
Diseases		Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)	Dowling-Degos disease Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
GWAS			Basal cell carcinoma ( 31174203 24403052 25855136 27539887) Cutaneous squamous cell carcinoma ( 32041948) Keratinocyte cancer (MTAG) ( 31174203) Non-melanoma skin cancer ( 29739929) Squamous cell carcinoma ( 31174203)
Interacting Genes		2 interacting genes: KRT5 LMNA	25 interacting genes: ALOX12 ALOX12B APC DSP DST EVPL INCA1 KIFC3 KRT1 KRT14 KRT15 KRT16 KRT18 KRT19 KRT24 KRT25 KRT27 KRT28 KRT31 KRT35 KRT38 KRT40 PKP2 TCHP UBE3A
Entrez ID		242	3852
HPRD ID		04772	01010
Ensembl ID		ENSG00000179477	ENSG00000186081
Uniprot IDs		O75342	P13647
PDB IDs			3TNU 6JFV
Enriched GO Terms of Interacting Partners?
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