TFIP11 and POLR1C

Data Source:
BioGRID (two hybrid)

		TFIP11	POLR1C
Description		tuftelin interacting protein 11	RNA polymerase I and III subunit C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Nuclear Speck Extracellular Matrix U2-type Post-mRNA Release Spliceosomal Complex Catalytic Step 2 Spliceosome	Nucleoplasm RNA Polymerase III Complex RNA Polymerase I Complex Cytosol
	Molecular Function	Nucleic Acid Binding Protein Binding	RNA Polymerase I Activity RNA Polymerase III Activity DNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Protein Dimerization Activity
	Biological Process	Spliceosomal Complex Disassembly MRNA Splicing, Via Spliceosome RNA Processing Biomineral Tissue Development Negative Regulation Of Protein-containing Complex Assembly Protection From Non-homologous End Joining At Telomere Negative Regulation Of Protein Binding Negative Regulation Of DNA Ligase Activity Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Transcription By RNA Polymerase I Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription By RNA Polymerase III Positive Regulation Of Type I Interferon Production Positive Regulation Of Gene Expression, Epigenetic
Pathways		mRNA Splicing - Major Pathway	Cytosolic sensors of pathogen-associated DNA NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs
Diseases			Treacher Collins syndrome
GWAS			GLP-1 levels in response to oral glucose tolerance test (fasting) ( 29093273) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		232 interacting genes: AARD ABI2 ABLIM3 AIMP2 ANKRD11 AP1M1 ARHGEF9 ARMC7 ARMCX1 ARNT2 ATP5PO ATPAF2 AXIN1 BAZ2B BCL6 BHLHA9 BMF BRD1 BYSL C1orf109 C2CD6 CARD9 CAVIN3 CBX8 CCDC102B CCDC116 CCDC120 CCDC121 CCDC13 CCDC146 CCDC187 CCDC196 CCDC42 CCDC57 CCDC6 CCDC68 CCDC96 CCHCR1 CCND3 CCNG1 CCNL1 CCP110 CDKN1A CDR2L CENPU CEP57 CEP57L1 CEP95 CFAP206 COQ8A COX5B CT55 CWF19L2 DAXX DDX25 DES DGCR6 DISC1 DPPA3 DTNB EAF2 EIF3A EIF3D ENOX2 EPM2AIP1 EXOC3L1 EXOC8 EXOSC5 FAM13C FAM156A FAM161A FAM161B FAM50B FAM81A FAM90A1 FANCG FGA GADD45GIP1 GAS2L2 GCC1 GCFC2 GEM GFAP GNG4 GOLGA1 GOLGA2 GPS2 GRAP2 GSE1 HAUS1 HDAC4 HIP1R HMG20B HOOK1 HSF2BP IKBIP IL16 IMP3 JRK KANK2 KANSL1 KAT5 KDM1A KIF3C KIF9 KIFC3 KIZ KRT1 KRT20 KRT6A KRT6B KRT6C KRT8 LATS1 LCA5 LCA5L LENG1 LIN37 LMNB2 LMO1 LMO2 LMO4 LSM3 LSP1P3 LYSMD1 MAB21L2 MCM7 MDM2 METTL17 MFAP1 MKRN3 MRPL11 MTFR2 MXD3 MYO15B MYOM1 NDC80 NDE1 NDN NEK6 NFKBID NFU1 NSMF NUP88 ODAD3 OIP5 PBX3 PBX4 PCM1 PDE4DIP PHF1 PIBF1 PICK1 PKN3 PLK4 POLL POLR1C POM121 PPFIA3 PPP1R16A PPP1R16B PPP1R18 PRPF31 PSMA4 PSMC5 PSTPIP1 PTCD1 RCOR3 RHNO1 RIN1 RNF6 RRP7A RUNX1T1 RXRB S100P SAP30BP SCNM1 SFR1 SGF29 SH2D4A SH3GLB1 SMARCB1 SMARCE1 SNAPIN SNRPB SNW1 SNX20 SNX32 SOGA1 SPG21 SSX2IP STRA8 STRN SYCE1 TBC1D30 TBRG4 TCAF1 TDP2 TFPT THAP7 THAP8 TNNT1 TP53 TRAF3IP3 TRAPPC4 TRIM45 TRIML2 TSG101 TSGA10IP TSHZ2 TSHZ3 TSPYL4 TUFT1 TXLNA TXN2 UBTFL1 USP2 USP6 USP7 VPS37C VPS39 WAC WASHC3 ZC2HC1C ZFYVE26 ZGPAT ZMAT2 ZNF417 ZNF572 ZNF587 ZNF777 ZSCAN12	119 interacting genes: ADAMTSL4 ARHGEF5 ATRIP AVPI1 BHLHB9 BIN3 BIRC7 BLZF1 C1orf105 C21orf58 C4orf45 CBX8 CBY2 CCDC33 CCNK CCT3 CGGBP1 CLU CORO1A CORO1B CRACR2A EFHC2 EP400 FH FMR1 FOXR2 GAS8 GMPPB GOLGA6A GOLGA6L9 GRPEL1 GSTO2 HDX HNRNPH1 HOXB9 HOXD12 IHO1 IKZF3 INCA1 KCTD1 KCTD13 KLF15 KRT19 KRT75 KRT76 KRTAP12-2 KRTAP3-1 LNX2 LRIF1 LZTS1 LZTS2 MBIP MEI4 MEOX2 MKRN3 MORN3 MRPS23 MYD88 MYO5B NDUFB10 NEDD4 NFKBIB NIF3L1 NME1 NME4 PIH1D2 POLDIP3 POLR1D POLR1E POLR1G POLR2G POLR2J POLR2J3 PPP2R3C PSMA1 RBM48 RIMBP3 RIMBP3C RSPH14 RUSC1 SAXO1 SMN1 SMN2 SORBS3 SPATC1L SPRY1 STMN3 TASOR2 TAX1BP1 TCF4 TEX43 TFIP11 TLE5 TMEM121 TNFAIP1 TNNI1 TRAIP TRIM14 TRIM27 TRIOBP TSC22D4 UNKL USP54 VIM WASHC1 WRN XPA YPEL3 ZBED1 ZBTB42 ZC2HC1C ZFP57 ZIM2 ZNF547 ZNF554 ZNF655 ZNF688 ZNF835 ZRANB1
Entrez ID		24144	9533
HPRD ID		11628	09661
Ensembl ID		ENSG00000100109	ENSG00000171453
Uniprot IDs		A0A024R1I7 Q9UBB9	O15160
PDB IDs
Enriched GO Terms of Interacting Partners?
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