POLR1C and BLZF1

Data Source:
BioGRID (two hybrid)

		POLR1C	BLZF1
Description		RNA polymerase I and III subunit C	basic leucine zipper nuclear factor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm RNA Polymerase III Complex RNA Polymerase I Complex Cytosol	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Golgi Apparatus
	Molecular Function	RNA Polymerase I Activity RNA Polymerase III Activity DNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Protein Dimerization Activity	Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding
	Biological Process	Transcription By RNA Polymerase I Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription By RNA Polymerase III Positive Regulation Of Type I Interferon Production Positive Regulation Of Gene Expression, Epigenetic	Golgi Organization Golgi To Plasma Membrane Protein Transport
Pathways		Cytosolic sensors of pathogen-associated DNA NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter	Golgi Cisternae Pericentriolar Stack Reorganization
Drugs
Diseases		Treacher Collins syndrome
GWAS		GLP-1 levels in response to oral glucose tolerance test (fasting) ( 29093273) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		119 interacting genes: ADAMTSL4 ARHGEF5 ATRIP AVPI1 BHLHB9 BIN3 BIRC7 BLZF1 C1orf105 C21orf58 C4orf45 CBX8 CBY2 CCDC33 CCNK CCT3 CGGBP1 CLU CORO1A CORO1B CRACR2A EFHC2 EP400 FH FMR1 FOXR2 GAS8 GMPPB GOLGA6A GOLGA6L9 GRPEL1 GSTO2 HDX HNRNPH1 HOXB9 HOXD12 IHO1 IKZF3 INCA1 KCTD1 KCTD13 KLF15 KRT19 KRT75 KRT76 KRTAP12-2 KRTAP3-1 LNX2 LRIF1 LZTS1 LZTS2 MBIP MEI4 MEOX2 MKRN3 MORN3 MRPS23 MYD88 MYO5B NDUFB10 NEDD4 NFKBIB NIF3L1 NME1 NME4 PIH1D2 POLDIP3 POLR1D POLR1E POLR1G POLR2G POLR2J POLR2J3 PPP2R3C PSMA1 RBM48 RIMBP3 RIMBP3C RSPH14 RUSC1 SAXO1 SMN1 SMN2 SORBS3 SPATC1L SPRY1 STMN3 TASOR2 TAX1BP1 TCF4 TEX43 TFIP11 TLE5 TMEM121 TNFAIP1 TNNI1 TRAIP TRIM14 TRIM27 TRIOBP TSC22D4 UNKL USP54 VIM WASHC1 WRN XPA YPEL3 ZBED1 ZBTB42 ZC2HC1C ZFP57 ZIM2 ZNF547 ZNF554 ZNF655 ZNF688 ZNF835 ZRANB1	101 interacting genes: AKAP9 AMOTL2 ANKS1A AQP1 BAG4 BANP BCL6 BEX2 CARD9 CCDC120 CCDC33 CCNH CDC37 CDK18 CFAP206 CHCHD3 CINP CKS2 CTNNA3 DNMT3L ENKD1 ERCC3 EWSR1 EXOC8 FAM124B FAM90A1 FBF1 FHL2 FRMD6 FRS3 GEM GORASP2 HCLS1 HDAC4 HOXA1 HOXC8 IGFN1 IKZF3 IL16 IQUB KANK2 KAT5 KCTD9 KDM1A KIF9 KLHL38 LGALS14 LMO1 LMO2 LMO3 LNX1 MID2 MISP MKRN3 NTAQ1 OAZ3 PCDHB12 PIK3R3 PKN1 POLR1C PRKAB2 PRMT6 PRPF18 PSMA1 PTPN11 RAB2A RAB2B RAB39A RANBP3 RHOJ SCNM1 SMAD3 SMARCB1 SPRED1 SRA1 SSX2 SUV39H2 SYT17 TBC1D22B TBC1D7 TCAP TCF19 TEKT4 TNS2 TRAPPC2L TRIM59 TSC22D4 TSTD2 TTC23 TXNDC5 USHBP1 VPS28 ZBTB16 ZBTB24 ZGPAT ZMAT1 ZNF124 ZNF410 ZNF688 ZNF76 ZZZ3
Entrez ID		9533	8548
HPRD ID		09661	16367
Ensembl ID		ENSG00000171453	ENSG00000117475
Uniprot IDs		O15160	Q9H2G9
PDB IDs
Enriched GO Terms of Interacting Partners?
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