GABARAPL1 and MEFV

Data Source:
BioGRID (pull down)

		GABARAPL1	MEFV
Description		GABA type A receptor associated protein like 1	MEFV innate immuity regulator, pyrin
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GO Annotations	Cellular Component	Autophagosome Membrane Mitochondrion Autophagosome Endoplasmic Reticulum Golgi Apparatus Cytosol Microtubule Cytoplasmic Vesicle Membrane Dendrite Membrane Dendrite Cytoplasm Cell Body	Ruffle Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol Microtubule Microtubule Associated Complex Lamellipodium Cytoplasmic Vesicle
	Molecular Function	Protein Binding Tat Protein Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding	Actin Binding Protein Binding Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Cellular Response To Nitrogen Starvation Macroautophagy Autophagosome Maturation	Inflammatory Response Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Response To Interferon-gamma Innate Immune Response Negative Regulation Of Inflammatory Response Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Cysteine-type Endopeptidase Activity
Pathways		Macroautophagy	The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs
Diseases			Familial Mediterranean fever (FMF); Familial hereditary periodic fever syndromes
GWAS			Ankylosing spondylitis ( 30946743)
Interacting Genes		73 interacting genes: AHNAK2 AMBRA1 ANK2 ATG13 ATG4A ATG4B ATG4D BNIP3L BSCL2 BSDC1 CALCOCO1 CALCOCO2 CREB3L2 CUL3 DISC1 DVL2 DYNLL1 ERBB2 ERBB3 FUNDC1 HSP90AA1 HSP90AB1 KBTBD7 KRTAP10-3 KRTAP10-7 KRTAP10-9 KXD1 MAPK15 MEFV MLX NEDD4 NFIA OPRK1 OPTN OSBPL3 PBXIP1 PSMB4 PTPRR RABGAP1 RABGAP1L RB1CC1 RCN2 RETREG3 SCYL3 SNCA SQSTM1 SRPK1 SRPK2 STRN3 TAX1BP1 TBC1D1 TBC1D10A TBC1D10B TBC1D16 TBC1D17 TBC1D2 TBC1D25 TBC1D2B TBC1D5 TBC1D7 TBC1D9 TBC1D9B THAP7 TMEM131 TNIP1 TP53INP1 TRIM21 TRIM32 ULK1 UMAD1 VDR WDFY3 ZBTB22	12 interacting genes: COG5 GABARAP GABARAPL1 GABARAPL2 LGALS3 LGALS8 MAP1LC3A MAP1LC3C PSTPIP1 PYCARD SIVA1 ULK1
Entrez ID		23710	4210
HPRD ID		07601	02012
Ensembl ID		ENSG00000139112	ENSG00000103313
Uniprot IDs		A0A024RAP5 Q9H0R8	D2DTW2 O15553
PDB IDs		2L8J 2R2Q 5DPT 5LXH 5LXI 6HOI 6HOL	2MPC 2WL1 4CG4
Enriched GO Terms of Interacting Partners?
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