STX12 and CISD2

Data Source:
BioGRID (two hybrid)

		STX12	CISD2
Description		syntaxin 12	CDGSH iron sulfur domain 2
Image
GO Annotations	Cellular Component	Golgi Membrane Phagophore Assembly Site Nucleoplasm Golgi Apparatus Synaptic Vesicle Endomembrane System Integral Component Of Membrane Integral Component Of Synaptic Vesicle Membrane BLOC-1 Complex SNARE Complex Early Endosome Membrane Vesicle Intracellular Membrane-bounded Organelle Membrane Raft Phagocytic Vesicle Recycling Endosome Membrane Postsynaptic Recycling Endosome	Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Protein-containing Complex Perinuclear Endoplasmic Reticulum
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding	RNA Binding Protein Binding Protein Homodimerization Activity Metal Ion Binding 2 Iron, 2 Sulfur Cluster Binding
	Biological Process	Autophagosome Assembly Intracellular Protein Transport Vesicle Fusion Cholesterol Efflux Vesicle Docking Protein Stabilization	Autophagy Of Mitochondrion Multicellular Organism Aging Regulation Of Autophagy
Pathways
Drugs
Diseases			Wolfram syndrome (WFS); DIDMOAD syndrome
GWAS			Asthma and attention deficit hyperactivity disorder ( 31619474) Estimated glomerular filtration rate ( 31152163) Primary biliary cholangitis ( 26394269) Schizophrenia ( 28991256) Type 2 diabetes ( 28869590)
Interacting Genes		43 interacting genes: AQP6 AQP8 BCL2L13 BLOC1S6 CD79A CISD2 DNAJC5 DTX2 EBP EEA1 EPB42 ERGIC3 FCER1G GORAB HOMER1 KASH5 LEPROTL1 LMNA MFSD6 MMGT1 NAPA NEMP1 NSG1 PDZK1IP1 PLPPR2 RIC3 SEC11C SLC10A6 SLC66A2 SNAP23 SNAP25 SNAP29 STX1A STX2 STX4 STXBP5L TIMMDC1 TLCD4 TMEM14B TMEM167B TMEM31 TMEM86B TMX2	58 interacting genes: AIG1 APOL2 APP AQP10 BCL2L2 BET1 BMP10 BTN2A2 C14orf180 C2CD2L C4orf3 CDIPT CFHR5 CLDN10 CLN6 CYBC1 EHHADH EMD FAM241B GALNT15 GAST GPR37L1 HHATL IER3 KIR2DL3 LEPROTL1 LRP10 MAN2B2 MIP NAPB NRG4 NSG1 PGAP2 PLPP4 PLPPR2 PNKP POMGNT1 RTP2 RUSF1 SEC22A SERP2 SLC13A3 SLC35B4 SMIM1 SNORC SPP1 STX12 STX7 THSD7B TMEM187 TMEM243 TMEM43 TMEM86A TSPAN33 TTPA VAMP4 VKORC1L1 YIPF6
Entrez ID		23673	493856
HPRD ID		06059	17413
Ensembl ID		ENSG00000117758	ENSG00000145354
Uniprot IDs		Q86Y82	Q8N5K1
PDB IDs		2DNX	3FNV 4OO7 4OOA
Enriched GO Terms of Interacting Partners?
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