ADAM15 and SORBS2

Data Source:
HPRD (in vitro)

		ADAM15	SORBS2
Description		ADAM metallopeptidase domain 15	sorbin and SH3 domain containing 2
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Space Plasma Membrane Adherens Junction Cell Surface Integral Component Of Membrane Motile Cilium Extracellular Exosome	Nucleus Plasma Membrane Focal Adhesion Actin Cytoskeleton Apical Plasma Membrane Z Disc Lamellipodium Perinuclear Region Of Cytoplasm
	Molecular Function	Metalloendopeptidase Activity Integrin Binding Protein Binding Metallopeptidase Activity SH3 Domain Binding Metal Ion Binding	RNA Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Anchor Activity Structural Constituent Of Muscle
	Biological Process	Angiogenesis Negative Regulation Of Cell-matrix Adhesion Immune Response To Tumor Cell Proteolysis Apoptotic Process Cell-matrix Adhesion Integrin-mediated Signaling Pathway Male Gonad Development Extracellular Matrix Disassembly Extracellular Matrix Organization Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Collagen Catabolic Process Tissue Regeneration Innate Immune Response Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Receptor Binding Cellular Response To Phorbol 13-acetate 12-myristate Response To Hypobaric Hypoxia	Actin Filament Organization Notch Signaling Pathway Biological_process Cell Growth Involved In Cardiac Muscle Cell Development
Pathways		Degradation of the extracellular matrix Invadopodia formation
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Eosinophil percentage of white cells ( 32888494) General risk tolerance (MTAG) ( 30643258) Mosquito bite size ( 28199695) Prostate cancer ( 23535732) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 28714469)	Cardiac Troponin-T levels ( 31014085) Coronary artery disease ( 33020668) Cytokine and corticosteroid-stimulated IL-6 production ( 25896417) Cytokine-stimulated IL-6 production ( 25896417) Height ( 31562340) Short-term memory (digit-span task) ( 30741946) Uterine fibroid size (maximum volume) ( 30196971) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		34 interacting genes: ABL1 ARHGEF6 ARHGEF7 ATXN1 BANP FHL3 FYN GRB2 HCK LCK LYN MAD2L2 NCK1 NPHP1 NUP62 ODAM PACSIN3 RBPMS SH3D19 SH3GL2 SH3GLB1 SH3PXD2A SH3RF1 SH3RF3 SNX30 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SP4 SRC TRIP13 YES1	45 interacting genes: ABI1 ABL1 ABL2 ACTN1 ACTN4 ADAM15 AFDN AKT1 AKT2 ATPAF2 CBL CBLB DLGAP1 DLGAP2 DLGAP4 EFS EGFR EIF3H FAT1 FLOT1 GOLGA2 MDM2 NCK2 NR1H2 PAK1 PAK2 PALLD PKM PTK2B PTPN12 RPL9 SEMA6A SH2D4A SH3RF1 SOCS7 SYNJ1 TEPSIN TRAF4 VCL VPS37C WAS WASF1 WASL YWHAE YWHAZ
Entrez ID		8751	8470
HPRD ID		05674	12473
Ensembl ID		ENSG00000143537	ENSG00000154556
Uniprot IDs		Q13444	B7Z3D7 B7Z997 O94875
PDB IDs			5VEI
Enriched GO Terms of Interacting Partners?
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