TARDBP and NACC1

Data Source:
BioGRID (pull down, pull down)

		TARDBP	NACC1
Description		TAR DNA binding protein	nucleus accumbens associated 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Perichromatin Fibrils Cytoplasmic Stress Granule Nuclear Speck Interchromatin Granule	Nucleus Nucleoplasm Cytoplasm Cell Junction Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Double-stranded DNA Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Identical Protein Binding Pre-mRNA Intronic Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Histone Deacetylase Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation MRNA Processing RNA Splicing Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Protein Stability Positive Regulation Of Insulin Secretion Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Import Into Nucleus Regulation Of Circadian Rhythm Regulation Of Apoptotic Process Negative Regulation By Host Of Viral Transcription Rhythmic Process Regulation Of Cell Cycle 3'-UTR-mediated MRNA Destabilization 3'-UTR-mediated MRNA Stabilization Nuclear Inner Membrane Organization	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Negative Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Beard thickness ( 26926045) Ewing sarcoma ( 22327514) Male-pattern baldness ( 22693459 28196072)	Obesity-related traits ( 23251661)
Interacting Genes		16 interacting genes: APP EXOSC10 FBXO7 FUS IRAK2 LSM6 MED6 NACC1 NSFL1C RACK1 RNF2 SETDB1 UBQLN1 XRN2 ZFAND2B ZHX1	19 interacting genes: BCOR C8orf33 EHHADH ELOA HDAC3 HDAC4 LGALS8 LSM3 PML POLR2L PRKCI PRPF18 PRPF3 SENP1 SENP2 TARDBP UBE2I UBTFL1 ZNF512B
Entrez ID		23435	112939
HPRD ID		05466	10692
Ensembl ID		ENSG00000120948	ENSG00000160877
Uniprot IDs		A0A024R4E2 Q13148 Q9H256	A0A024R7E0 Q96RE7
PDB IDs		1WF0 2CQG 2N2C 2N3X 2N4G 2N4H 2N4P 4BS2 4IUF 4Y00 4Y0F 5MDI 5MRG 5W50 5W52 5W7V 5WHN 5WHP 5WIA 5WIQ 5WKB 5WKD 5X4F 6B1G 6CF4 6CFH 6N37 6N3A 6N3B 6N3C 6T4B	3GA1 4U2N
Enriched GO Terms of Interacting Partners?
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